1127405-04-2Relevant academic research and scientific papers
Solvent-free one-pot oxidation of ethylarenes for the preparation of α-ketoamides under mild conditions
Liu, Fuyan,Zhang, Kuan,Liu, Yanfeng,Chen, Shan,Chen, Yiping,Zhang, Dela,Lin, Chunfu,Wang, Bo
, p. 7158 - 7162 (2017/02/05)
Here we developed a highly efficient solvent-free, one-pot procedure for synthesizing α-ketoamides from ethylarenes and amines, by oxidizing a C-H bond sp3 center. A copper catalyst was employed, and the reactions proceeded smoothly at ambient temperatures. Most of the tested ethylarenes and amines were successfully converted to their corresponding α-ketoamides in moderate to excellent yields of up to 93% with three equivalents of the oxidant tert-butyl hydroperoxide.
One pot synthesis of α-ketoamides from ethylarenes and amines: a metal free difunctionalization strategy
Ramanathan, Mani,Kuo, Chun-Kai,Liu, Shiuh-Tzung
, p. 11446 - 11453 (2016/12/16)
One-pot and metal free synthesis of α-ketoamides has been described through in situ generation of aryl ketones from easily available ethylarenes followed by amidation with various amines. This multiple oxidation protocol involves catalytic I2-pyridine-TBHP (t-butyl hydroperoxide) mediated oxidative benzylic carbonylation and sequential NaI-TBHP mediated oxidative amidation without using any solvent.
A general and efficient copper catalyst for the double carbonylation reaction
Liu, Jianming,Zhang, Rongzhao,Wang, Shoufeng,Sun, Wei,Xia, Chungu
supporting information; experimental part, p. 1321 - 1324 (2009/09/24)
The use of (NHC)Cul complex in combination with a N-heterocyclic carbene precursor as catalyst for the double carbonylation of aryl Iodides and secondary amines solves the problem of using the precious metal Pd and phosphine ligands. The new protocol requ
