1127499-07-3

Upstream product

• 36953-37-4 4-bromo-2(1H)-pyridinone 
• 7051-34-5 cyclopropylcarbinyl bromide 

Downstream Products

• 1127498-00-3 3-chloro-1-(cyclopropylmethyl)-4-(4-phenyl-1-piperidyl)pyridin-2-one 
• 1213766-65-4 (2aα,3α,3aα)-3-chloro-1-cyclopropylmethyl-4-(6-phenyl-3-aza-bicyclo[3.1.0]hex-3-yl)-1H-pyridin-2-one 
• 1213766-63-2 (2aα,3α,3aα)-1-cyclopropylmethyl-4-(6-phenyl-3-aza-bicyclo[3.1.0]hex-3-yl)-1H-pyridin-2-one 
• 1127499-62-0 1'-cyclopropylmethyl-2'-oxo-4-phenyl-3,4,5,6,1',2'-hexahydro-2H-[1,4']bipyridinyl-4-carbonitrile 
• 1127499-56-2 1-(cyclopropylmethyl)-4-(4-phenyl-1-piperidyl)pyridin-2-one 
• 1127500-08-6 4-(1'-cyclopropylmethyl-2'-oxo-3,4,5,6,1',2'-hexahydro-2H-[1,4']bipyridinyl-4-yl)-benzoic acid 

Relevant academic research and scientific papers

NOVEL COMPOUNDS AS NADPH OXIDASE INHIBITORS

The present invention is related to new compounds, pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).

HETEROARYLBENZIMIDAZOLE COMPOUNDS

The present invention covers heteroarylbenzimidazole compounds of general formula (I) in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative and/or inflammatory disorders, as a sole agent or in combination with other active ingredients.