36953-37-4

Basic information

• Product Name: 4-BROMOPYRIDIN-2-OL
• Synonyms: 4-Iodoopyridin-2(1H)-one;4-BROMO-2-PYRIDINOL;4-BROMO-2-HYDROXYPYRIDINE;4-BROMOPYRIDIN-2-OL;4-Iodo-1H-pyridin-2-one;2-HYDROXY-4-BROMOPYRIDINE;4-IODOPYRIDIN-2(1H)-ONE;4-Iodo-1H-pyridin-2-one 97%
• CAS NO: 36953-37-4
• Molecular Formula: C₅H₄BrNO
• Molecular Weight: 174
• Product Categories: Pyridine Series;pharmacetical;Halides;Pyridines;Pyridine;Heterocycle-Pyridine series
• Mol File: 36953-37-4.mol
• Article Data: 6

Chemical Properties

• Melting Point: 186 °C
• Boiling Point: 305.9 °C at 760 mmHg
• Flash Point: 138.8 °C
• Appearance: White/Crystalline Powder
• Density: 1.776 g/cm³
• Vapor Pressure: 0.418mmHg at 25°C
• Refractive Index: 1.543
• Storage Temp.: Room temperature.
• PKA: 10.54±0.10(Predicted)
• CAS DataBase Reference: 4-BROMOPYRIDIN-2-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMOPYRIDIN-2-OL(36953-37-4)
• EPA Substance Registry System: 4-BROMOPYRIDIN-2-OL(36953-37-4)

Safety Data

• Statements: 36/38
• Safety Statements: 36
• Hazardous Substances Data: 36953-37-4(Hazardous Substances Data)

Usage

Uses

4-Bromo-2-hydroxypyridine is used as a reagent to synthesize trans-3,4’-bispyridinylethylenes, compounds that act as inhibitors of protein kinase B that are used to treat cancer.

InChI:InChI=1/C6H6BrNO/c1-9-6-4-5(7)2-3-8-6/h2-4H,1H3

Upstream product

• 73583-37-6 2-chloro-4-bromopyridine 
• 84249-14-9 2-amino-4-bromopyridine 
• 14432-12-3 4-Amino-2-chloropyridine 
• 960298-00-4 2-(benzyloxy)-4-bromopyridine 
• 1214900-01-2 2-(benzyloxy)pyridin-4-amine 
• 100367-39-3 4-bromo-2-methoxypyridine 

Downstream Products

• 1001076-61-4 C₂₂H₂₇N₃O₂S 
• 889865-56-9 4-bromo-1-(2-hydroxyethyl)pyridin-2(1H)-one 
• 1237534-53-0 2-(4-bromo-pyridin-2-yloxy)-2-methyl-propionic acid methyl ester 
• 1193334-89-2 3-(4-bromo-2-oxo-2H-pyridin-1-yl)-2-methyl-propionic acid methyl ester 
• 1237534-49-4 4-bromo-1-[(S)-tetrahydro-furan-3-yl]-1H-pyridin-2-one 
• 1237534-50-7 4-bromo-2-[(S)-tetrahydro-furan-3-yloxy]-pyridine 
• 1193334-88-1 4-bromo-1-(2-hydroxy-2-methyl-propyl)-1H-pyridin-2-one 
• 1254730-45-4 C₁₄H₁₈BrNO₃ 
• 67970-80-3 1-methyl-4-phenyl-2(1H)-pyridone 
• 1445865-67-7 2-{4-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]-2-oxo-1,2-dihydropyridin-1-yl}acetic acid 

Relevant articles and documents

NOVEL COMPOUNDS AS NADPH OXIDASE INHIBITORS

The present invention is related to new compounds, pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).

Concise Entries to 4-Halo-2-pyridones and 3-Bromo-4-halo-2-pyridones

Methods for the synthesis of both simple 4-halo-2-pyridones and more functionalized 3,4-di- and (3,4,5-tri)-halo-2-pyridones are described that are based on a combination of Sandmeyer and regioselective (copper-mediated) halogenation, with a 2-chloro or a 2-benzyloxy moiety serving as a masked 2-pyridone.

Intrinsic electrophilicity of the 4-methylsulfonyl-2-pyridone scaffold in glucokinase activators: Role of glutathione-S-transferases and in vivo quantitation of a glutathione conjugate in rats

Previous studies on the in vitro metabolism of 4-alkylsulfonyl-2-pyridone- based glucokinase activators revealed a facile, non-enzymatic displacement of the 4-alkylsulfonyl group by glutathione. In the present studies, a role for glutathione-S-transferases (GST) as catalysts in the desulfonylation reaction was demonstrated using a combination of human liver microsomes, human liver cytosol and human GSTs. The identification of a glutathione conjugate in circulation following intravenous administration of a candidate 4-methylsulfonyl-2-pyridone to rats confirmed the relevance of the in vitro findings.