112753-54-5Relevant academic research and scientific papers
Compound capable of effectively inhibiting or killing multi-drug resistant bacteria and preparation method and application of compound
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Paragraph 0185; 0708, (2017/06/02)
The invention discloses a compound capable of effectively inhibiting or killing bacterial microorganisms. The compound has a structural general formula shown as the formula I (please see the formula in the description). Pharmacodynamic experiments prove that the compound can effectively inhibit or kill the broad-spectrum and multi-drug resistant staphylococcus aureus, streptococcus pneumoniae and staphylococcus aureus and is expected to be developed into a novel effective antibacterial drug with new targets.
Design, synthesis, and anti-influenza viral activities of 1,3-diarylprop-2-en-1-ones: A novel class of neuraminidase inhibitors
Kinger, Mayank,Park, Yong Dae,Park, Jeong Hoon,Hur, Min Goo,Jeong, Hyung Jae,Park, Su-Jin,Lee, Woo Song,Kim, Sang Wook,Yang, Seung Dae
experimental part, p. 633 - 638 (2012/09/21)
A series of 1,3-diarylprop-2-en-1-one derivatives 3a-v have been synthesized and evaluated for their ability to inhibit neuraminidase (NA). Among the prepared compounds, the less lipophilic derivative 3k showed the most potent in vitro inhibitory activity against NA with an IC50 value of 1.5 μM.
Synthesis and In Vitro Antifungal Evaluation of 1,3,5-Trisubstituted-2-Pyrazoline Derivatives
Deng, Hui,Yu, Zhi-Yi,Shi, Guan-Ying,Chen, Ming-Jing,Tao, Ke,Hou, Tai-Ping
experimental part, p. 279 - 289 (2012/05/20)
Pyrazolines, the well-known five-membered nitrogen-containing heterocyclic compounds, have received considerable interests in the fields of medicinal and agricultural chemistry because of their broad spectrum of biological activities. To discover more pot
