112755-94-9

Upstream product

• 92007-38-0 cis-bicyclo[3.3.0]octane-3,7-dione 3,7-bis(2',2'-dimethylpropylidene) acetal 
• 74513-16-9 bicyclo[3.3.0]octane-3,7-dione 
• 126-30-7 2,2-Dimethyl-1,3-propanediol 
• 51716-63-3 cis-bicyclo[3. 3. 0]octane-3,7-dione 

Downstream Products

• 930-99-4 cis-bicyclo<3.3.0>oct-2-ene 
• 19915-11-8 (3aRS,6aSR)-hexahydro-2(1H)-pentalenone 
• 92007-51-7 C₂₀H₂₆O₃Se 
• 597557-38-5 (-)-(E,3aS,4S,5R,6aS)-{5-(tert-butyldimethylsilanyloxy)-4-[(3S)-tert-butyldimethylsilanyloxy-4S-methylnona-1,6-diynyl]-hexahydropentalen-2-ylidene}acetic acid 2R-(1-methyl-1-phenylethyl)-1S-cyclohexyl ester 
• 597557-62-5 (3aS,5R,6S,6aS)-{5-(tert-butyldimethylsilanyloxy)-6-[(3S,4S)-3-tert-butyldimethylsilanyloxy-4-methylnona-1,6-diynyl]-1,3a,4,5,6,6a-hexahydropentalen-2-yl}acetic acid [(2R,1S)-2-(1-methyl-1-phenylethyl)-1-cyclohexyl ester] 

Relevant academic research and scientific papers

Synthesis of functionalized pentalenes via carbonyl-ene reaction and enzymatic kinetic resolution

The synthesis of functionalized pentalene derivatives is described. Bicyclo[3.3.0]octane-3,7-dione 5 (Weiss diketone) was converted in six steps into the silyl-protected 3-methylbicyclo[3.3.0]octenol 6, which was submitted to Lewis acid catalyzed carbonyl

The Silicon-Hydrogen Exchange Reaction: A Catalytic σ-Bond Metathesis Approach to the Enantioselective Synthesis of Enol Silanes

The use of chiral enol silanes in fundamental transformations such as Mukaiyama aldol, Michael, and Mannich reactions as well as Saegusa-Ito dehydrogenations has enabled the chemical synthesis of enantiopure natural products and valuable pharmaceuticals. However, accessing these intermediates in high enantiopurity has generally required the use of either stoichiometric chiral precursors or stoichiometric chiral reagents. We now describe a catalytic approach in which strongly acidic and confined imidodiphosphorimidates (IDPi) catalyze highly enantioselective interconversions of ketones and enol silanes. These "silicon-hydrogen exchange reactions"enable access to enantiopure enol silanes via tautomerizing σ-bond metatheses, either in a deprotosilylative desymmetrization of ketones with allyl silanes as the silicon source or in a protodesilylative kinetic resolution of racemic enol silanes with a carboxylic acid as the silyl acceptor.

HETEROCYCLIC COMPOUNDS, COMPOSITIONS COMPRISING HETEROCYCLIC COMPOUND, AND METHODS OF USE THEREOF

Disclosed herein are compounds of formula I and/or a stereoisomer, stable isotopologue, and/or pharmaceutically acceptable salts thereof; and therapeutic uses of these compounds, which are inhibitors of tryptophan 2, 3-dioxygenase 2 (TDO2) and/or indoleam

THIENOPYRIMIDINE DERIVATIVE AND USE THEREOF IN MEDICINE

The present invention relates to a thienopyrimidine derivative and use thereof in medicine, and also to a pharmaceutical composition containing the compound. The compound or pharmaceutical composition is used for inhibiting acetyl-CoA carboxylase (ACC). The present invention also relates to a method of preparing such compound and pharmaceutical composition, as well as their use in the treatment or prevention of diseases regulated by acetyl-CoA carboxylase in mammals, especially in humans.

Octahydrocyclopentadiene derivative with beta2 receptor agonisis and M receptor antagonism activity, and use thereof in medicines

The invention relates to an octahydrocyclopentadiene derivative with beta2 receptor agonisis and M receptor antagonism activity, and a use thereof in medicines, and concretely relates to a compound represented by general formula (I), or a stereoisomer, a hydrate, a metabolite, a solvate, a pharmaceutically acceptable salt, a eutectic crystal or a prodrug of the compound, a preparation method of the compound, and an application of the compound in the preparation of medicines for treating airway obstructive disease. The formula of the compound of represented by general formula (I) is shown in the description, and all substituent groups in the formula are as defined in the description.

HEXAHYDROPENTALENO DERIVATIVES, PREPARATION METHOD AND USE IN MEDICINE THEREOF

The invention relates to hexahydropentaleno derivatives, the preparation method and use in medicine thereof, and in particular to hexahydropentaleno derivatives or stereo-isomers or pharmaceutically acceptable salts thereof as shown in general formula (I), and to the preparation method therefor and pharmaceutical compositions comprising the derivatives, and to the use thereof as a therapeutical agent, especially as a DPP-IV inhibitor. The definition of each substituent in formula (I) is the same as the definition in the description.

Versatile Route to centro-Substituted Triquinacene Derivatives: Synthesis of 10-Phenyltriquinacene

(Equation Presented) A versatile route to prepare centro-substituted triquinacene derivatives (1, R = various substituents), as exemplified by the preparation of 10-phenyltriquinacene (1, R = Ph), is reported. The quaternary, centro substituent (C-10) was installed by a trimethylsilyl chloride-promoted conjugate addition reaction of an organocuprate, derived from phenylmagnesium bromide, and the protected bicyclic enone (11). The resultant trimethylsilyl enol ether was then converted regioselectively to the C-2-allylated conjugate addition products (13, R = Ph). The allyl moiety, following oxidative cleavage of the carbon-carbon double bond, was used to elaborate the tricyclic ring system by an intramolecular aldol/ acetal deprotection reaction. The product of this reaction was then converted to the target compound using a standard series of functional group transformation reactions.

THERMAL REARRANGEMENT OF DIVINYLCYCLOPROPANE SISTEMS. A NEW FORMAL TOTAL SYNTHESIS OF (+/-)-QUADRONE

The key step of a new approach to the total synthesis of the structurally and physiologically interesting sesquiterpenoid (+/-)-quadrone (1) involves thermal (Cope) rearrangement of the higly functionalized divynilcyclopropane derivative 8.The product 9 of this process is converted into 19, thus completing a formal total synthesis of (+/-)-1.

SYNTHESIS OF cis-BICYCLOOCT-3-ENE-2,7-DIONE, A HIGHLY FUNCTIONALIZED CYCLOPENTANOID INTERMIDIATE

cis-Bicyclooct-3-ene-2,7-dione (1) has been synthesized either from cis-bicyclooctane-3,7-dione (2) or the -cycloadduct 10 of 5-trimethylsilylcyclopentadiene with dichloroketene.As anticipated, the conjugated double bond of acetal 9 act