112758-38-0

Upstream product

• 141-97-9 ethyl acetoacetate 
• 21487-45-6 1,3-diphenyl-4-formylpyrazole 

Downstream Products

• 1346141-83-0 diethyl 4-(1,3-diphenyl-1H-pyrazol-4-yl)-2,6-dimethylpyridine-3,5-dicarboxylate 

Relevant academic research and scientific papers

Pumice-based sulfonic acid: a sustainable and recyclable acidic catalyst for one-pot synthesis of pyrazole anchored 1,4-dihydropyridine derivatives at room temperature

In the present investigation, we have developed an efficient and eco-friendly protocol for the synthesis of pyrazole anchored 1,4-dihydropyridine analogs using pumice-based sulfonic acid (pumice@SO3H) as a recyclable solid acid catalyst under s

Silica-supported ceric ammonium nitrate (CAN): a simple, mild and solid-supported reagent for quickest oxidative aromatization of Hantzsch 1,4-dihydropyridines

An efficient and environmentally benign methodology for the oxidative aromatization of 1,4-dihydropyridines to their corresponding pyridine derivatives is developed. The oxidative aromatization of 1,4-dihydropyridines was explored using silica-supported ceric ammonium nitrate as catalyst in CH3CN with or without sonication at room temperature. This supported catalyst acts as a more efficient oxidising reagent and offers several advantages over other reported reagents in terms of reaction time and yields. The supported reagent is found to be more efficient and selective when compared with its unsupported form. The Belousov–Zhabotinskii reaction was not observed in present reaction. The dealkylation observed in case of 4-n-alkyl/n-alkenyl with other oxidising agents is also not observed in the present case.

CAN mediated mechanochemical synthesis of substituted pyridine derivatives

A simple, green and cost-effective protocol has been devised for the synthesis of 4-substituted-2,6-dimethyl-3,5-pyridinecarboxylates from Hantzsch-type 1,4-dihydropyridines via rapid oxidation in excellent yields using 1.5 equivalent of ceric ammonium nitrate within 15 minutes in solvent-free conditions. The method was able to furnish the products in excellent yields. The products obtained were characterized by their NMR and melting points data.

Ionic liquid [HNMP][HSO4] promoted one pot synthesis of 1,4-dihydropyridine derivatives at room temperature

Background: An efficient and green synthesis of various diethyl-1,4-dihydro-2,6-dimethyl-4-(3-aryl-1-phenyl-1H-pyrazol-4-yl)pyridine-3,5-dicarboxylate derivatives was achieved by the multicomponent condensation of 3-aryl-1-phenyl-1H-pyrazole-4-carboxaldeh

Recyclable Bi2WO6-nanoparticle mediated one-pot multicomponent reactions in aqueous medium at room temperature

Different types of multicomponent reactions (MCRs) are reported using Bi2O3, BiVO4, and Bi2WO6 (nanoparticle) as heterogeneous catalysts. Among these, Bi2WO6 nanoparticles showed excellent reactivity for the synthesis of functionalized dihydropyridine, polyhydroquinoline, 4H-chromene and 2-amino-4H-benzo[b]pyran derivatives at ambient temperature in aqueous medium. All the reactions gave good to excellent yields in 10-45 minutes in the presence of 5 mol% (optimized) of the catalyst. The catalyst was regenerated and reused up to 5 times without losing catalytic activity. The gram scale synthesis of dihydropyridine gave the desired product in 82% yield in 2 h. This journal is

Solvent-free synthesis of diethyl-1,4-dihydro-2,6-dimethyl-4-(1,3-diaryl- 1H-pyrazole-4-yl)/cycloalkyl pyridine-3,5-dicarboxylates as potent antimicrobial agents

A facile synthesis of new series of diethyl-1,4-dihydro-2,6-dimethyl-4-(1, 3-diaryl-1H-pyrazole-4-yl)/cycloalkyl pyridine-3,5-dicarboxylates has been accomplished by stirring a mixture of 1,3-diaryl -1H-pyrazole-4-carbaldehyde/ cycloalkylcarbaxaldehyde, e

Iodobenzene diacetate (IBD) catalyzed an quick oxidative aromatization of Hantzsch-1,4-dihydropyridines to pyridines under ultrasonic irradiation

This project was undertaken to demonstrate the potential of iodobenzene diacetate for the oxidative aromatization of Hantzch-1,4-dihydropyridines under ultrasonic irradiation. All reactions were carried out under ultrasonic irradiation and results were co

An efficient, three-component one-pot preparation of 1,4-dihydropyridines containing novel substituted pyrazole under sulfamic acid catalysis

An efficient approach to 1,4-dihydropyridines containing novel substituted pyrazole is achieved via threecomponent reaction of pyrazolyl aldehyde, β-ketoester, and ammonium acetate in one-pot under sulfamic acid catalysis.

Synthesis and biological evaluation of some novel 1,4-dihydropyridines as potential antitubercular agents

Recent studies showed that 1,4-dihydropyridine-3,5-dicarbamoyl derivatives with lipophilic groups have significant antitubercular activity. In this study, we have synthesized new derivatives of 1,4-dihydropyridines bearing carbmethoxy and carbethoxy group