112758-96-0Relevant articles and documents
Combating Enhanced Intracellular Survival (Eis)-Mediated Kanamycin Resistance of Mycobacterium tuberculosis by Novel Pyrrolo[1,5-a]pyrazine-Based Eis Inhibitors
Garzan, Atefeh,Willby, Melisa J.,Ngo, Huy X.,Gajadeera, Chathurada S.,Green, Keith D.,Holbrook, Selina Y. L.,Hou, Caixia,Posey, James E.,Tsodikov, Oleg V.,Garneau-Tsodikova, Sylvie
, p. 302 - 309 (2017)
Tuberculosis (TB) remains one of the leading causes of mortality worldwide. Hence, the identification of highly effective antitubercular drugs with novel modes of action is crucial. In this paper, we report the discovery and development of pyrrolo[1,5-a]p
Iridium-catalyzed asymmetric hydrogenation of pyrrolo[1,2- a ]pyrazinium salts
Huang, Wen-Xue,Yu, Chang-Bin,Shi, Lei,Zhou, Yong-Gui
supporting information, p. 3324 - 3327 (2014/07/08)
Highly enantioselective iridium-catalyzed hydrogenation of pyrrolo[1,2-a]pyrazinium salts has been achieved, providing a direct access to chiral 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine derivatives with up to 95% ee. The key feature of the reaction is the addition of cesium carbonate, which increases the conversion and prohibits the racemization pathway of products.