112770-07-7Relevant academic research and scientific papers
SYNTHESIS OF N--ACETOHYDROXAMIC ACIDS, POTENTIAL INHIBITORS OF THE 5-LIPOXYGENASE
Svoboda, Jiri,Palecek, Jaroslav
, p. 1317 - 1332 (2007/10/02)
The synthesis of the title compounds starts from methyl (3-subst.phenoxy)alkanoates II which are reduced to the corresponding aldehydes and then transformed to oximes V by reaction with hydroxylamine.Reduction with borane-pyridine complex gives the hydroxylamines VI which on diacetylation and partial deacetylation provide the hydroxamic acids VIII.
