112777-67-0

Basic information

• Product Name: (R)-(+)-1-(3'-chlorophenyl)propan-1-ol
• Synonyms: (R)-(+)-1-(3'-chlorophenyl)propan-1-ol;(R)-1-(3-chlorophenyl)propanol
• CAS NO: 112777-67-0
• Molecular Formula: C₉H₁₁ClO
• Molecular Weight: 170.63604
• Mol File: 112777-67-0.mol
• Article Data: 73

Chemical Properties

• Boiling Point: 247.5±15.0 °C(Predicted)
• Appearance: /
• Density: 1.145±0.06 g/cm3(Predicted)
• PKA: 14.16±0.20(Predicted)
• CAS DataBase Reference: (R)-(+)-1-(3'-chlorophenyl)propan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-1-(3'-chlorophenyl)propan-1-ol(112777-67-0)
• EPA Substance Registry System: (R)-(+)-1-(3'-chlorophenyl)propan-1-ol(112777-67-0)

Safety Data

• Hazardous Substances Data: 112777-67-0(Hazardous Substances Data)

Usage

General Description

"(R)-(+)-1-(3'-chlorophenyl)propan-1-ol" is a chemical compound with a specific stereochemical configuration. It is an alcohol with a propanol backbone and a chlorophenyl group attached to the first carbon. (R)-(+)-1-(3'-chlorophenyl)propan-1-ol has potential applications in organic synthesis, pharmaceuticals, and research. Its stereochemistry may be important in determining its biological activity and interactions with other molecules. Researchers and chemists may be interested in studying its properties and potential uses in various fields.

Upstream product

• 557-20-0 diethylzinc 
• 104-88-1 4-chlorobenzaldehyde 
• 587-04-2 m-Chlorobenzaldehyde 
• 34841-35-5 3'-chloro-propiophenone 
• 873-63-2 m-chlorobenzyl alcohol 
• 32019-30-0 (+/-)-1-(3'-chlorophenyl)propan-1-ol 
• 97-93-8 triethylaluminum 
• 497165-73-8 (R)-(+)-1-(3'-chlorophenyl)propyl acetate 
• 108-05-4 vinyl acetate 

Relevant articles and documents

Facile synthesis of enantiopure 1,1′-spirobiindane-7,7′-diol and its 4,4′-derivatives: Application in enantioselective addition of diethylzinc to aromatic aldehydes

The enantiopure 1,1′-spirobiindane-7,7′-diol (SPINOL) and its 4,4′-derivatives 4,4′-diiodo-1,1′-spirobiindane-7,7′- diol (DISPINOL) and 4,4′-dimethyl-1,1′-spirobiindane-7,7′-diol (DMSPINOL) have been synthesized effectively via (1S)-(-)-4,4′-dibromo-1, 1′

Novel, cyclic and bicyclic 1,3-diols as catalysts for the diethylzinc addition to aldehydes

A number of optically pure 1,3-diols have been synthesized and used as catalysts in the asymmetric addition of diethylzinc to aromatic aldehydes. Enantiomeric excesses of up to 92% of (R)-1-phenylpropan-1-ol were obtained with anisylbicyclo[2.2.2]octanedi

Enantioselective Addition of Diethylzinc to Aromatic Aldehydes Using Novel Thiophene-Based Chiral Ligands

Abstract: Chiral norephedrine-derived β-amino alcohols with a thiophene moiety were synthesized from thiophene carbaldehydes (methyl- or ethyl-substituted) and chiral amino alcohols, such as both enantiomers of norephedrine and 2-aminopropanol. The synthesized ligands were applied to the catalytic asymmetric addition of diethylzinc to aldehydes to obtain optically active alcohols with a high conversion (92%) and excellent enantioselectivities (ee up to 99%). The highest enantioselectivity (ee 99%) was obtained with p-trifluorobenzaldehyde as the substrate containing the strongly electron-acceptor CF3 group.

Isosterically designed chiral catalysts: Rationale, optimization and their application in enantioselective nucleophilic addition to aldehydes

Proline-based N,N′-dioxide ligands were designed on the basis of isosteric approach, and were successfully applied in enantioselective nucleophilic addition to aldehydes. In the presence of 10 mol% of chiral ligand 1b, enantioselective addition of diethylzinc to aldehydes provided the corresponding secondary alcohols in up to 90% isolated yield and up to 99% ee. Similarly, using 3e as chiral ligand, enantioselective arylation and alkynylation of aldehydes also proceeded readily, leading to the desired chiral alcohols in up to 92% isolated yield at 99% ee and 80% isolated yields and up to 84% ee, respectively. The current work would shed light on expanding the structure diversity in the design of chiral ligands and chiral catalysts.