112778-82-2

Upstream product

• 586-37-8 1-(3-Methoxyphenyl)ethanone 
• 934-32-7 1H-benzimidazol-2-amine 
• 58316-11-3 3-dimethylamino-1-(3-methoxy-phenyl)-2-propen-1-one 
• 58316-11-3 3-(dimethylamino)-1-(3-methoxyphenyl)prop-2-en-1-one 

Relevant academic research and scientific papers

For detecting imaging agent of neurological disorders

Imaging agents of formulas (I)-(V) and methods for detecting neurological disorders comprising administering to a patient in need compounds of formulas (I)-(V) capable of binding to tau proteins and β-amyloid peptides are presented herein. The invention also relates to methods of imaging Aβ and tau aggregates comprising introducing a detectable quantity of pharmaceutical formulation comprising a radiolabeled compound of formulas (I)-(V) and detecting the labeled compound associated with amyloid deposits and/or tau proteins in a patient. These methods and compositions enable preclinical diagnosis and monitoring progression of AD and other neurological disorders.

A Simple Regioselective Synthesis of Pyrimidobenzimidazoles

2-Aminobenzimidazoles were reacted with enaminones in acetic acid to give pyrimidobenzimidazoles.With a substituted enaminone only one regioisomer was obtained.Structural assignments based on nmr and uv spectroscopy are presented.Possible pathways