112778-83-3Relevant academic research and scientific papers
For detecting imaging agent of neurological disorders
-
, (2016/10/08)
Imaging agents of formulas (I)-(V) and methods for detecting neurological disorders comprising administering to a patient in need compounds of formulas (I)-(V) capable of binding to tau proteins and β-amyloid peptides are presented herein. The invention also relates to methods of imaging Aβ and tau aggregates comprising introducing a detectable quantity of pharmaceutical formulation comprising a radiolabeled compound of formulas (I)-(V) and detecting the labeled compound associated with amyloid deposits and/or tau proteins in a patient. These methods and compositions enable preclinical diagnosis and monitoring progression of AD and other neurological disorders.
A Simple Regioselective Synthesis of Pyrimidobenzimidazoles
Tseng, Shin-Shyong,Epstein, Joseph W.,Brabander, Herbert J.,Francisco, Gerardo
, p. 837 - 843 (2007/10/02)
2-Aminobenzimidazoles were reacted with enaminones in acetic acid to give pyrimidobenzimidazoles.With a substituted enaminone only one regioisomer was obtained.Structural assignments based on nmr and uv spectroscopy are presented.Possible pathways
