1127896-89-2Relevant academic research and scientific papers
Efficient Synthesis of a (Z)-3-Methyleneisoindolin-1-one Library Using Cu(OAc)2·H2O/DBU under Microwave Irradiation
Zhang, Li,Zhang, Yongliang,Wang, Xin,Shen, Jingkang
, p. 654 - 665 (2013/03/14)
Microwave-promoted efficient synthesis of a (Z)-3-methyleneisoindolin-1-one library from 2-bromobenzamides and terminal alkynes using Cu(OAc) 2·H2O/DBU is described. Various benzamide substituents, ring substitutions, including heter
Microwave assisted copper-free Sonogashira coupling/5-exo-dig cycloisomerization domino reaction: Access to 3-(phenylmethylene)isoindolin-1- ones and related heterocycles
Hellal, Malik,Cuny, Gregory D.
, p. 5508 - 5511 (2011/10/31)
An efficient microwave assisted one-pot synthesis of substituted 3-(phenylmethylene)isoindolin-1-ones is reported via a copper-free Sonogashira coupling and a regioselective 5-exo-dig cycloisomerization. This domino reaction was also extended to other related heterocycles.
Assembly of substituted 3-methyleneisoindolin-1-ones via a cul/l-proline-catalyzed domino reaction process of 2-bromobenzamides and terminal alkynes
Li, Li,Wang, Miao,Zhang, Xiaojing,Jiang, Yongwen,Ma, Dawei
supporting information; experimental part, p. 1309 - 1312 (2009/08/07)
Cul/L-proline catalyzed coupling of 2-bromobenzamides and terminal alkynes in i-Pr0H (or DMF and DMSO) at 85-110 °C and subsequent additive cyclization produces substituted 3-methyleneisoindolin-1-ones. Variation of N-substituents, aromatic ring, and meth
