336129-03-4

Upstream product

• 22921-68-2 2-bromo-5-methoxy-benzoic acid 
• 100-46-9 benzylamine 
• 56658-04-9 2-bromo-5-methoxybenzoyl chloride 

Downstream Products

• 1160855-50-4 2-benzyl-4-(1-hydroxyethylidene)-7-methoxy-4H-isoquionoline-1,3-dione 
• 183313-29-3 5-methoxy-2-benzylbenzo[d]isothiazol-3(2H)-one 
• 1127896-89-2 (Z)-2-benzyl-3-benzylidene-6-methoxy-2,3-dihydro-isoindol-1-one 
• 1401880-81-6 5-benzyl-8-methoxyphenanthridin-6(5H)-one 
• 1347749-17-0 2-benzyl-5-methoxybenzo[d][1,2]selenazol-3(2H)-one 

Relevant academic research and scientific papers

Rapid construction of C4-substituted phenanthridinones through palladium-catalyzed domino N-arylation/aryl-aryl coupling process

An excellent chemo- and regioselective palladium-catalyzed cascade intermolecular N-arylation/aryl-aryl coupling process has been developed. Employing Pd(TFA)2, PCy3?HBF4, K2CO3 and 1,4-dioxane in an oil bath at 100°C for 12 h, diverse C4-substituted phenanthridinones are synthesized from o-bromobenzamides in 42-92% yield. Broad substrate scope and excellent functional group tolerance are observed. The synthetic utility of this method is illustrated by the further derivatization to prepare multiple-substituted phenanthridinones in 30-75% yield.

Microwave assisted copper-free Sonogashira coupling/5-exo-dig cycloisomerization domino reaction: Access to 3-(phenylmethylene)isoindolin-1- ones and related heterocycles

An efficient microwave assisted one-pot synthesis of substituted 3-(phenylmethylene)isoindolin-1-ones is reported via a copper-free Sonogashira coupling and a regioselective 5-exo-dig cycloisomerization. This domino reaction was also extended to other related heterocycles.

Efficient synthesis of phenanthridinone derivatives via a palladium-catalyzed coupling process

(Chemical Equation Presented) A palladium-mediated domino reaction was developed to conveniently synthesize phenanthridinone derivatives. Phosphine ligand 1 strongly promotes the domino process, which includes aryl-aryl coupling and C-N bond formations concomitant with a deamidation reaction. The versatility and applicability to a broad range of substrates make this reaction useful for the development of bioactive derivatives.

A useful acylation method using trichloroacetonitrile and triphenylphosphine for solid phase organic synthesis

A novel acylation procedure was developed for polymer supported synthesis, with in situ generated acyl chlorides using trichloroacetonitrile and triphenylphosphine.