112790-42-8Relevant articles and documents
Dolabellane-type diterpenoids with antiprotozoan activity from a southwestern caribbean gorgonian octocoral of the genus Eunicea
Wei, Xiaomei,Rodriguez, Abimael D.,Baran, Peter,Raptis, Raphael G.
experimental part, p. 925 - 934 (2010/09/09)
Ten new diterpenes, 1-10, having a dolabellane skeleton were isolated from a Colombian gorgonian coral of the genus Eunicea. Their structures, as well as those of known compounds 11-18, were determined on the basis of spectroscopic analysis and, in some instances, by chemical conversion and X-ray crystallographic analysis. The absolute structure of 7 was established by chemical conversion from 11, a co-occurring dolabellane congener of known absolute structure. Most of these diterpenoids showed antimalarial activity against the protozoan parasite Plasmodium falciparum.
Total synthesis of dolabellane diterpenoid claenone
Miyaoka, Hiroaki,Isaji, Yutaka,Kajiwara, Yasuhiro,Kunimune, Iyo,Yamada, Yasuji
, p. 6503 - 6506 (2007/10/03)
Marine dolabellane diterpenoid claenone (1) was synthesized from D- mannitol. This synthesis involves the formation of bicyclo[2.2.1] heptane derivative 4a by sequential Michael reaction, the formation of cyclopentane derivative 9 by retro-aldol reaction