Journal of Medicinal Chemistry p. 806 - 811 (1991)
Update date:2022-07-31
Topics:
Atwal
Swanson
Unger
Floyd
Moreland
Hedberg
O'Reilly
In order to explain the potent antihypertensive activity of the modestly active (IC50 = 3.2 μM) dihydropyrimidine calcium channel blocker 5, we carried out drug metabolism studies in the rat and found 5 is metabolized to compounds 6-10. Two of
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