Dihydropyrimidine calcium channel blockers. 3. 3-carbamoyl-4-aryl-1,2,3,4-tetrahydro-6-methyl-5-pyrimidinecarboxylic acid esters as orally effective antihypertensive agents

DOI: 10.1021/jm00106a048

Source and publish data:

Journal of Medicinal Chemistry p. 806 - 811 (1991)

Update date:2022-07-31

Topics:

Authors:

Atwal Atwal

Swanson Swanson

Unger Unger

Floyd Floyd

Moreland

Hedberg Hedberg

O'Reilly

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Article abstract of DOI:10.1021/jm00106a048

In order to explain the potent antihypertensive activity of the modestly active (IC₅₀ = 3.2 μM) dihydropyrimidine calcium channel blocker 5, we carried out drug metabolism studies in the rat and found 5 is metabolized to compounds 6-10. Two of

Full text of DOI:10.1021/jm00106a048

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