1127976-77-5Relevant academic research and scientific papers
Enantioselective β-Alkylation of Aldehydes through an Organocatalyzed C-C Bond-Scission Reaction
Huang, Huicai,Abbaraju, Santhi,Zhao, John C.-G.
, p. 1379 - 1382 (2016)
A novel organocatalyzed C-C bond-scission reaction of saturated aldehydes containing a suitable leaving group at the β-position was used for the in situ formation of iminium intermediates, which were then captured by nucleophiles to achieve a direct enantioselective β-alkylation of aldehydes. Within short reaction times, the corresponding β-alkylated aldehyde products were obtained in high yields (48-87%) and with excellent enantioselectivities (84-98%).
Base-base bifunctional catalysis: A practical strategy for asymmetric Michael addition of malonates to α,β-unsaturated aldehydes
Wang, Yongcan,Li, Pengfei,Liang, Xinmiao,Yea, Jinxing
supporting information; experimental part, p. 1383 - 1389 (2009/06/18)
Lewis base-Bronsted base bifunctional catalysis is a novel and practical strategy for the asymmetric Michael addition. The addition of malonates to a series of α,β-unsaturated aldehydes can take place under base-base bifunctional catalytic conditions using 0.5-5 mol% of (S)-2-[diphenyl(trimethylsilyloxy) methyl]pyrrolidine as catalyst and 5-30 mol% of lithium 4-fluorobenzoate as additive base with up to 99% ee.
Lithium bis[(1R,5R)-3-aza-3-benzyl-1,5-diphenylpentan-1,5-diolato]- aluminium - A new heterobimetallic catalyst for Michael addition reactions
Manickam,Sundararajan
, p. 2721 - 2736 (2007/10/03)
The C2-symmetric amino diol, (1R,5R)-3-aza-3-benzyl-1,5-diphenyl pentan-1, 5-diol, 1 [(R,R)-1] reacts with LiAlH4 to give the heterobimetallic complex 2 of the composition [(12-Al)Li]. Complex 2 was characterised by 1
