112807-63-3

Upstream product

• 112807-66-6 1-Phenyl-2-methyl-4-oxoindeno<1,2-b>pyrrole 
• 75-36-5 acetyl chloride 
• 485-47-2 indan-1,2,3-trione hydrate 
• 62-53-3 aniline 
• 123-54-6 acetylacetone 
• 115979-15-2 4-Acetyl-2-(2-carboxy-phenyl)-5-methyl-1-phenyl-1H-pyrrole-3-carboxylic acid 
• 82577-26-2 1-Phenyl-2-methyl-3-carboxy-4-oxoindeno<1,2-b>pyrrole 
• 82577-12-6 2-Methyl-4-oxo-1-phenyl-1,4-dihydro-indeno[1,2-b]pyrrole-3-carboxylic acid ethyl ester 
• 115979-04-9 2-(4-Acetyl-5-methyl-1-phenyl-1H-pyrrol-2-yl)-benzoic acid 

Downstream Products

• 104927-22-2 1-Phenyl-2-methyl-4-oxoindeno<1,2-b>pyrrolyl-3-glyoxal bisulfite derivative 

Relevant academic research and scientific papers

One-pot three-component reaction of ninhydrin, 1,3-dicarbonyl compounds, and primary amines to afford indeno[1,2-b]pyrrol-4(1H)-ones

[Figure not available: see fulltext.] A convenient one-pot three-component synthesis of indeno[1,2-b]pyrrol-4(1H)-ones has been developed. The reaction of ninhydrin, 1,3-dicarbonyl compounds, and primary amines in the presence of PPh3 in MeCN at room temperature produces the respective indeno-[1,2-b]pyrrol-4(1H)-ones in high yields. The synthesized pyrrole derivatives have been used in the Diels–Alder reaction with dialkyl acetylenedicarboxylates in MeCN under reflux conditions to obtain indeno[1,2-b]pyrano[3,4-d]pyrroles in high yields.

INTRAMOLECULAR CYCLIZATION OF 5-(o-CARBOXYPHENYL)PYRROLE DERIVATIVES

A new method is proposed for the synthesis of derivatives of indeno-pyrrole-4-ones by intramolecular cyclization of the corresponding 5-(o-carboxyphenyl)pyrroles by trifluoroacetic anhydride.