112811-67-3

Basic information

• Product Name: Propanedioic acid, (2,4,5-trifluoro-3-methoxybenzoyl)-, diethyl ester
• CAS NO: 112811-67-3
• Molecular Formula: C15H15F3O6
• Molecular Weight: 348.276
• Mol File: 112811-67-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Propanedioic acid, (2,4,5-trifluoro-3-methoxybenzoyl)-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedioic acid, (2,4,5-trifluoro-3-methoxybenzoyl)-, diethyl ester(112811-67-3)
• EPA Substance Registry System: Propanedioic acid, (2,4,5-trifluoro-3-methoxybenzoyl)-, diethyl ester(112811-67-3)

Safety Data

• Hazardous Substances Data: 112811-67-3(Hazardous Substances Data)

Upstream product

• 112811-66-2 2,4,5-trifluoro-3-methoxybenzoyl chloride 
• 105-53-3 diethyl malonate 
• 13332-24-6 1-bromo-3-methoxy-2,4,5-trifluorobenzene 
• 112811-63-9 3-methoxy-2,4,5-trifluorobenzonitrile 
• 112811-64-0 2,4,5-trifluoro-3-methoxy-benzamide 
• 112811-65-1 3-methoxy-2,4,5-trifluorobenzoic acid 
• 37892-24-3 potassium diethyl malonate 
• 2414-98-4 magnesium ethylate 

Downstream Products

• 364069-19-2 ethyl 6,7-difluoro-1-[(1R,2S)-2-fluorocyclopropyl]-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate 
• 122375-85-3 ethyl 3-ethoxy-2-(2,4,5-trifluoro-3-methoxybenzoyl)acrylate 
• 112811-70-8 ethyl 3-(cyclopropylamino)-2-(2,4,5-trifluoro-3-methoxybenzoyl)acrylate 
• 112811-60-6 1-Cyclopropyl-6-fluoro-8-methoxy-7-(3-amino-1-pyrrolidinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid 
• 146981-09-1 5-amino-7-(3-amino-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid 
• 112811-71-9 ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate 
• 160738-57-8 gatifloxacin 
• 112811-72-0 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid 
• 112811-75-3 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methylaminomethyl-1-pyrrolidinyl)-4-oxo-3-quinolinecarboxylic acid 
• 112811-68-4 ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate 

Relevant articles and documents

Synthesis, antimycobacterial and antibacterial evaluation of l-[(1R, 2S)-2-fluorocyclopropyl]fluoroquinolone derivatives containing an oxime functional moiety

A series of novel 1-[(1R, 2S)-2-fluorocyclopropyl]fluoroquinolone derivatives 9aed containing an oxime functional moiety were synthesized and evaluated for their biological activity. Our results reveal that 9a1 and 9b3 have good in vitro activity against MTB H37Rv ATCC 27294 (MIC: 0.25 mg/mL) and two MDR-MTB clinical isolates (MICs: 0.065-0.125 mg/mL). Most of 9aed show potent activity against Escherichia coli and Klebsiella pneumoniae (MICs: 50s: 11.43-26.04 mg/kg).

PROCESS FOR PRODUCING QUINOLONECARBOXYLIC ACID DERIVATIVE

Through a production process according to the following reaction scheme, compounds (2) which are useful for antibacterial agents can be provided at low cost and high yield.

8-alkoxyquinolonecarboxylic acid and salts thereof

Quinolonecarboxylic acid derivatives of the following formula: STR1 wherein R indicates a hydrogen atom or lower alkyl group, R1 indicates a lower alkyl group, R2 indicates a hydrogen atom, amino group or nitro group, X indicates a halogen atom, and Z indicates a halogen atom, piperazino group, N-methylpiperazino group, 3-methylpiperazino group, 3-hydroxypyrrolidino group, or pyrrolidino group of the following formula, STR2 (here, n is 0 or 1, R3 indicates a hydrogen atom or lower alkyl group, R4 indicates a hydrogen atom, lower alkyl group and R5 indicates a hydrogen atom, lower alkyl group, acyl group or alkoxycarbonyl group), the hydrates and pharmaceutically acceptable salts thereof are useful as antibacterial agents.