112830-95-2

Basic information

• Product Name: HU-210
• Synonyms: HU-210 DEA Schedule I;(6aR)-trans-3-(1,1-Dimethylheptyl)-6a,7,10,10a-tetrahydro-1-hydroxy-6,6-dimethyl-(6H)-dibenzo[b.d]pyran-9-methanol;(-)-11-OH-Δ8-THC-1,1-dimethylheptyl;(6aR)-6aβ,7,10,10aα-Tetrahydro-1-hydroxy-6,6-dimethyl-3-(1,1-dimethylheptyl)-6H-dibenzo[b,d]pyran-9-methanol;(6aR)-6aβ,7,10,10aα-Tetrahydro-6,6-dimethyl-1-hydroxy-3-(1,1-dimethylheptyl)-6H-dibenzo[b,d]pyran-9-methanol;[6aR,(-)]-6a,7,10,10aα-Tetrahydro-1-hydroxy-6,6-dimethyl-3-(1,1-dimethylheptyl)-6H-dibenzo[b,d]pyran-9-methanol;11-OH-Δ8-THC-1,1-dimethylheptyl;(6aR,10aR)-3-(1,1-Dimethylheptyl)-6a,7,10,10a-tetrahydro-1-hydroxy-6,6-dimethyl-6H-dibenzo[b,d]pyran-9-methanol
• CAS NO: 112830-95-2
• Molecular Formula: C₂₅H₃₈O₃
• Molecular Weight: 386.57
• EINECS: 200-659-6
• Product Categories: Cannabinoid receptor;Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 112830-95-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 470.1°Cat760mmHg
• Flash Point: 9℃
• Appearance: /solid
• Density: 1.03g/cm³
• Vapor Pressure: 6.93E-10mmHg at 25°C
• Refractive Index: 1.525
• Storage Temp.: −20°C
• Solubility: DMSO: soluble
• PKA: 9.72±0.60(Predicted)
• BRN: 4298162
• CAS DataBase Reference: HU-210(CAS DataBase Reference)
• NIST Chemistry Reference: HU-210(112830-95-2)
• EPA Substance Registry System: HU-210(112830-95-2)

Safety Data

• Hazard Codes: F,T
• Statements: 11-23/24/25-39/23/24/25
• Safety Statements: 7-16-36/37-45
• RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
• WGK Germany: 3
• Hazardous Substances Data: 112830-95-2(Hazardous Substances Data)

Usage

Description

HU-210 (exempt preparation) (Item No. 90083) is an analytical reference standard categorized as a synthetic cannabinoid. HU-210 is regulated as a Schedule I compound in the United States. HU-210 (exempt preparation) (Item No. 90083) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.

Chemical Properties

liquid

Uses

A synthetic agonist analog of ?9-Tetrahydro Cannabinol (T293200), which is the primary psychoactive component of marijuana. HU-210 is a potent central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptor agonist. It binds to neuroblastoma cell membrane CB1 receptors with about the same affinity as CP-55940. Controlled Substance.

Biological Activity

A highly potent cannabinoid receptor agonist (K i values are 0.061 and 0.52 nM at cloned human CB 1 and CB 2 receptors respectively). Induces spatial memory deficits and suppresses hippocampal firing rates in rats. Also displays agonist activity at GPR55 (EC 50 = 26 nM). Also available as part of the Cannabinoid Receptor Agonist Tocriset? .

InChI:InChI=1/C25H38O3/c1-6-7-8-9-12-24(2,3)18-14-21(27)23-19-13-17(16-26)10-11-20(19)25(4,5)28-22(23)15-18/h13-15,19-20,26-27H,6-12,16H2,1-5H3/t19-,20-/m0/s1

Upstream product

• 113418-02-3 2,2-Dimethyl-propionic acid (6aR,10aR)-3-(1,1-dimethyl-heptyl)-1-hydroxy-6,6-dimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-9-ylmethyl ester 
• 76163-96-7 2,2-Dimethyl-propionic acid (1R,5R)-6,6-dimethyl-4-oxo-bicyclo[3.1.1]hept-2-en-2-ylmethyl ester 
• 76163-97-8 2,2-Dimethyl-propionic acid (1R,5R)-4-hydroxy-6,6-dimethyl-bicyclo[3.1.1]hept-2-en-2-ylmethyl ester 
• 76163-95-6 (1R,5S)-2-[(2,2-dimethylpropoyloxy)methyl]-6,6-dimethylbicyclo[3.1.1]hept-2-ene 
• 19894-97-4 (1R)-Myrtenol 
• 56469-10-4 5-(1',1'-dimethyl-n-heptyl)-1,3-dihydroxybenzene 

Downstream Products

• 140835-14-9 [3H]-HU 243 

Related news

Cannabinoids & Stress: Impact of HU-210 (cas 112830-95-2) on behavioral tests of anxiety in acutely stressed mice07/24/2019

Anxiety disorders are one of the most prevalent classes of mental disorders affecting the general population, but current treatment strategies are restricted by their limited efficacy and side effect profiles. Although the cannabinoid system is speculated to be a key player in the modulation of ...detailed

Relevant articles and documents

SYNTHESIS OF THE INDIVIDUAL, PHARMACOLOGICALLY DISTINCT, ENANTIOMERS OF A TETRAHYDROCANNABINOL DERIVATIVE

The individual enantiomers of the 1,1-dimethylheptyl homolog of 7-hydroxy-Δ6-tetrahydrocannabinol, (1) and (2a), which exhibit distinct pharmacological profiles, have been obtained with very high e.e. by synthesis from the antipodes of myrtenol.