(6aR,10aR)-9-(hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol

Base Information

• Chemical Name: (6aR,10aR)-9-(hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol
• CAS No.: 112830-95-2
• Deprecated CAS: 182205-63-6
• Molecular Formula: C₂₅H₃₈O₃
• Molecular Weight: 386.575
• Hs Code.: 29329990
• UNII: 191042422P
• DSSTox Substance ID: DTXSID30150188
• Nikkaji Number: J442.046B
• Wikipedia: HU-210
• Wikidata: Q411905
• Pharos Ligand ID: DXKU8QDZSGHP
• ChEMBL ID: CHEMBL307696
• Mol file: 112830-95-2.mol

Synonyms:1,1-dimethylheptyl-11-hydroxytetrahydrocannabinol;1,1-dimethylheptyl-7-hydroxy-delta(6)-tetrahydrocannabinol;11-hydroxy-delta(8) -tetrahydrocannabinol-dimethylheptyl;11-hydroxy-delta-8-DMH-THC;11-hydroxymethyl-delta(8)-tetrahydrocannabinol-dimethylheptyl;11-OH-delta(8)-THC-DMH;5'(1,1-dimethylheptyl)-7-hydroxyhexahydrocannabinol;6H-Dibenzo(b,d)pyran-9-methanol, 3-(1,1-dimethylheptyl)-6a,7,10,10a-tetrahydro-1-hydroxy-6,6-dimethyl-, (6aS-trans)-;7-hydroxy-delta-6-tetrahydrocannabinoldimethylheptyl;dexanabinol;HU 210;HU 211;HU 211, (6aR-trans)-isomer;HU-210;HU-211;HU210

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of (6aR,10aR)-9-(hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol

Chemical Property:

• Appearance/Colour: solid
• Vapor Pressure: 6.93E-10mmHg at 25°C
• Refractive Index: 1.525
• Boiling Point: 470.1°Cat760mmHg
• PKA: 9.72±0.60(Predicted)
• Flash Point: 238.1°C
• PSA: 49.69000
• Density: 1.03g/cm³
• LogP: 6.22350
• Storage Temp.: −20°C
• Solubility.: DMSO: soluble
• XLogP3: 6.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 7
• Exact Mass: 386.28209507
• Heavy Atom Count: 28
• Complexity: 550

Purity/Quality:

Safty Information:

• Pictogram(s): F,T
• Hazard Codes: F,T
• Statements: 11-23/24/25-39/23/24/25
• Safety Statements: 7-16-36/37-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCCCCCC(C)(C)C1=CC(=C2C3CC(=CCC3C(OC2=C1)(C)C)CO)O
• Isomeric SMILES: CCCCCCC(C)(C)C1=CC(=C2[C@@H]3CC(=CC[C@H]3C(OC2=C1)(C)C)CO)O
• Description: HU-210 (exempt preparation) (Item No. 90083) is an analytical reference standard categorized as a synthetic cannabinoid. HU-210 is regulated as a Schedule I compound in the United States. HU-210 (exempt preparation) (Item No. 90083) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.
• Uses: A synthetic agonist analog of ?9-Tetrahydro Cannabinol (T293200), which is the primary psychoactive component of marijuana. HU-210 is a potent central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptor agonist. It binds to neuroblastoma cell membrane CB1 receptors with about the same affinity as CP-55940. Controlled Substance.

Technology Process of (6aR,10aR)-9-(hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol

There total 6 articles about (6aR,10aR)-9-(hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(1',1'-dimethyl-n-heptyl)-1,3-dihydroxybenzene (56469-10-4) → dexanabinol (112924-45-5,137428-19-4,112830-95-2)

Guidance literature:

Multi-step reaction with 2 steps

1: boron trifluoride etherate / CH₂Cl₂ / -20 °C

2: lithium aluminum hydride

With lithium aluminium tetrahydride; boron trifluoride diethyl etherate; In dichloromethane;

DOI:10.1016/S0957-4166(00)86322-3

Reference yield:

(1R)-Myrtenol (19894-97-4) → dexanabinol (112924-45-5,137428-19-4,112830-95-2)

Guidance literature:

Multi-step reaction with 5 steps

2: sodium chromate / acetic acid; acetic anhydride / 72 h / 35 °C

3: lithium tri-tert-butoxyaluminohydride / tetrahydrofuran

4: boron trifluoride etherate / CH₂Cl₂ / -20 °C

5: lithium aluminum hydride

With lithium aluminium tetrahydride; sodium chromate(VI); lithium tri(t-butoxy)aluminum hydride; boron trifluoride diethyl etherate; In tetrahydrofuran; dichloromethane; acetic anhydride; acetic acid;

DOI:10.1016/S0957-4166(00)86322-3

Reference yield:

(1R,5S)-2-[(2,2-dimethylpropoyloxy)methyl]-6,6-dimethylbicyclo[3.1.1]hept-2-ene (76163-95-6) → dexanabinol (112924-45-5,137428-19-4,112830-95-2)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium chromate / acetic acid; acetic anhydride / 72 h / 35 °C

2: lithium tri-tert-butoxyaluminohydride / tetrahydrofuran

3: boron trifluoride etherate / CH₂Cl₂ / -20 °C

4: lithium aluminum hydride

With lithium aluminium tetrahydride; sodium chromate(VI); lithium tri(t-butoxy)aluminum hydride; boron trifluoride diethyl etherate; In tetrahydrofuran; dichloromethane; acetic anhydride; acetic acid;

DOI:10.1016/S0957-4166(00)86322-3

upstream raw materials:

2,2-Dimethyl-propionic acid (6aR,10aR)-3-(1,1-dimethyl-heptyl)-1-hydroxy-6,6-dimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-9-ylmethyl ester

5-(1',1'-dimethyl-n-heptyl)-1,3-dihydroxybenzene

(1R)-Myrtenol

(1R,5S)-2-[(2,2-dimethylpropoyloxy)methyl]-6,6-dimethylbicyclo[3.1.1]hept-2-ene

Downstream raw materials:

[3H]-HU 243

Refernces