1129-72-2Relevant academic research and scientific papers
An aryne triggered ring-opening fluorination of cyclic thioethers with potassium fluoride
Fan, Rong,Liu, Binbin,Zheng, Tianyu,Xu, Kun,Tan, Chen,Zeng, Tianlong,Su, Shuaisong,Tan, Jiajing
, p. 7081 - 7084 (2018)
Herein, we report an aryne triggered ring-opening fluorination protocol of a great variety of saturated sulfur heterocycles. A key factor for the success is the identification of a suitable mediator. Compared to previous methods, this transition-metal free protocol employs low-cost potassium fluoride as the fluorine source. The operational simplicity and mild reaction conditions allow for the rapid synthesis of a wide range of aliphatic fluoride compounds in good yields.
