112913-95-8

Basic information

• Product Name: N-(MORPHOLIN-2-YLMETHYL)ACETAMIDE
• Synonyms: N-(MORPHOLIN-2-YLMETHYL)ACETAMIDE;Acetamide, N-(2-morpholinylmethyl)-
• CAS NO: 112913-95-8
• Molecular Formula: C₇H₁₄N₂O₂
• Molecular Weight: 158.19826
• Mol File: 112913-95-8.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(MORPHOLIN-2-YLMETHYL)ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(MORPHOLIN-2-YLMETHYL)ACETAMIDE(112913-95-8)
• EPA Substance Registry System: N-(MORPHOLIN-2-YLMETHYL)ACETAMIDE(112913-95-8)

Safety Data

• Hazardous Substances Data: 112913-95-8(Hazardous Substances Data)

Upstream product

• 110859-47-7 (4-benzylmorpholin-2-yl)methanamine 
• 110859-48-8 N-[(4-benzyl-2-morpholinyl)methyl]phthalimide 
• 40987-25-5 N-benzyl-2-chloromethylmorpholine 
• 112913-96-9 2-(N-acetylaminomethyl)-4-benzylmorpholine 

Downstream Products

• 112887-58-8 N-{4-[2-(4-Fluoro-phenoxy)-ethyl]-morpholin-2-ylmethyl}-acetamide 
• 112887-55-5 2-acetylaminomethyl-4-[3-(4-chlorophenoxy)propyl]morpholine 
• 112887-50-0 N-{4-[3-(4-Nitro-phenoxy)-propyl]-morpholin-2-ylmethyl}-acetamide 
• 112913-94-7 2-<(acetylamino)methyl>-4-(4-fluorobenzyl)morpholine 
• 1184662-33-6 2-acetylaminomethyl-4-[{1-(tert-butoxycarbonyl)-4-piperidinyl}methyl]morpholine 
• 112886-77-8 4-Amino-N-(4-benzo[d]isoxazol-3-ylmethyl-morpholin-2-ylmethyl)-5-chloro-2-methoxy-benzamide 
• 112886-68-7 4-Amino-5-chloro-N-{4-[6-(4-fluoro-phenoxy)-hexyl]-morpholin-2-ylmethyl}-2-methoxy-benzamide 
• 112886-70-1 4-Amino-5-chloro-N-{4-[5-(4-fluoro-phenoxy)-pentyl]-morpholin-2-ylmethyl}-2-methoxy-benzamide 
• 112886-27-8 4-Amino-5-chloro-2-ethoxy-N-{4-[4-(4-fluoro-phenyl)-4-oxo-butyl]-morpholin-2-ylmethyl}-benzamide 
• 112886-72-3 4-Amino-5-chloro-N-{4-[4-(4-fluoro-phenoxy)-butyl]-morpholin-2-ylmethyl}-2-methoxy-benzamide 
• 141815-01-2 4-Amino-5-chloro-2-ethoxy-N-{4-[3-(4-fluoro-phenylsulfanyl)-propyl]-morpholin-2-ylmethyl}-benzamide 
• 112886-63-2 4-Amino-5-chloro-N-{4-[4-(4-fluoro-phenyl)-4-oxo-butyl]-morpholin-2-ylmethyl}-2-methoxy-benzamide 
• 112913-78-7 4-amino-N-<<4-<3-(4-aminophenoxy)propyl>-2-morpholinyl>methyl>-5-chloro-2-methoxybenzamide 
• 112886-30-3 4-Amino-5-chloro-N-{4-[2-(4-chloro-phenoxy)-ethyl]-morpholin-2-ylmethyl}-2-ethoxy-benzamide 

Relevant articles and documents

AMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

Disclosed is a compound having a strong affinity to serotonin-4 receptors, which is useful as an enterokinesis-promoting agent or a digestive tract function-improving agent. Specifically, disclosed is a compound represented by Formula (1) or a pharmaceutically acceptable salt thereof. Also specifically disclosed is a pharmaceutical composition containing a compound represented by Formula (1) or a pharmaceutically acceptable salt thereof. [In Formula (1), Ar represents a group represented by Formula (Ar-1) or Formula (Ar-2).]

Pyrimidine derivatives

Pyrimidine derivatives useful as a gastrointestinal prokinetic agent, represented by formula STR1 wherein X is O or NR5, Y is O, S or NR5 wherein R5 is a hydrogen atom, a C1 -C6 alkyl group or the like; R1 and R2 may be the same or different and each is a hydrogen atom, a C1 -C6 alkyl group or the like; R3 is CN, or COOR6 wherein R6 is a C1 -C6 alkyl group, a C3 -C6 cycloalkyl group, an aryl group or the like; R4 is --SR7 or --NR8 R9 wherein R7 is a C1 -C6 alkyl group; R8 is a C1 -C6 alkyl group or the like; R9 is a hydrogen atom, a C1 -C6 alkyl group or the like, or R8 and R9 may represent, together with the nitrogen atom to which they are attached, an N-substituted piperazine ring of formula (X) STR2 wherein R10 represents a C1 -C6 alkyl group or the like or a pharmacologically acceptable salt thereof. The above-mentioned compounds are useful as a gastrointestinal prokinetic agent used for the therapy of digestive tract diseases.

Novel benzamides as selective and potent gastrokinetic agents. III. Synthesis and structure-activity relationships of 4-amino-5-chloro-2-methoxy- and 2-ethoxy-N-[(4-substituted 2-morpholinyl)methyl]-benzamides

A series of 4-amino-5-chloro-2-methoxy- and 2-ethoxy-N-[(4-substituted 2-morpholinyl)methyl]benzamides (11-44) were prepared and evaluated for gastrokinetic activity by determining their effects on the gastric emptying of phenol red semisolid meal in rats. The N-4 substituent includes alkyl, phenoxyalkyl, (4-fluorobenzoyl)alkyl, and heteroarylmethyl groups. The benzamide derivatives, having an isopropyl, isoamyl, neopentyl, 3-(4-chlorophenoxy)propyl, or pyridylmethyl group at N-4, showed potent in vivo gastric emptying activity. In particular, 4-amino-5-chloro-2-ethoxy-N-[[4-(3-pyridylmethyl)-2-morpholinyl]methyl ]benzamide (57b) was equipotent to the 4-fluorobenzyl analogue 1b (AS-4370 as its citrate) in the gastrokinetic activity on phenol red semisolid meal in rats and mice, and on resin pellet solid meal in rats. Moreover, compound 57b was free from dopamine D2 receptor antagonistic activity in both in vitro ([3H]spiperone binding) and in vivo (apomorphine-induced emesis in dogs) tests. Structure-activity relationships of compounds with various substituents at N-4 are also discussed.