1129540-90-4

Upstream product

• 3819-88-3 1-fluoro-3-iodo-5-nitrobenzene 
• 1051899-19-4 4-(3-iodo-5-nitrophenyl)-morpholine 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 1312572-91-0 N,N-bis(2-{[tert-butyl-(diphenyl)silyl]oxy}ethyl)-5-[3-(morpholin-4-yl)-5-nitrophenyl]-1,3-thiazol-2-amine 
• 1312572-93-2 N-[3-{2-[bis(2-{[tert-butyl(diphenyl)silyl]oxy}ethyl)amino]-1,3-thiazol-5-yl}-5-(morpholin-4-yl)phenyl]-4-(trifluoromethyl)pyrimidin-2-amine 
• 1312572-92-1 5-[3-amino-5-(morpholin-4-yl)phenyl]-N,N-bis(2-{[tert-butyl(diphenyl)silyl]oxy}ethyl)-1,3-thiazol-2-amine 
• 1312572-26-1 2,2'-({5-[3-(morpholin-4-yl)-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl]-1,3-thiazol-2-yl}imino)diethanol 
• 1312503-17-5 dicyclopropyl{5-[3-(morpholin-4-yl)-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl]-1,3-thiazol-2-yl}methanol 
• 1312537-01-1 {5-[3-amino-5-(morpholin-4-yl)phenyl]-1,3-thiazol-2-yl}(dicyclopropyl)methanol 

Relevant academic research and scientific papers

SUBSTITUTED PYRIDINE SPLEEN TYROSINE KINASE (Syk) INHIBITORS

The invention provides certain substituted pyridines of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, Rcy,Cy, and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.

AMINOPYRIMIDINES AS SYK INHIBITORS

The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.

AMINOPYRIMIDINES AS SYK INHIBITORS

The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.

SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS

The present invention provides novel substituted pyrimidinyl-amines that are useful as inhibitors of protein kinases, especially c-Jun N-terminal kinases (JNK) and pharmaceutical compositions thereof and methods of using the same for treating conditions responsive to the inhibition of the JNK pathway.