1129692-90-5Relevant academic research and scientific papers
An efficient and practical protocol for the production of pretomanid (PA-824) via a novel synthetic strategy
Chen, Guojun,Zhu, Minglin,Chen, Yuxiang,Miao, Xiuqi,Guo, Ming,Jiang, Nan,Zhai, Xin
, p. 3937 - 3945 (2020)
Abstract: An improved, practical and efficient protocol for the production of pretomanid (1) is described. Key to this optimization was the design and development of a novel synthetic strategy, which involves the preparation of key intermediate (S)-1-(ter
Preparation method of nitroimidazole pyran antituberculotic drug
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, (2019/12/02)
The invention relates to a preparation method of a nitroimidazole pyran antituberculotic candidate drug PA-824. The method comprises five reaction steps, and specially comprises the following steps: firstly, carrying out nucleophilic substitution, hydroly
Structure-activity relationships of antitubercular nitroimidazoles. 2. determinants of aerobic activity and quantitative structure-activity relationships
Kim, Pilho,Kang, Sunhee,Boshoff, Helena I.,Jiricek, Jan,Collins, Margaret,Singh, Ramandeep,Manjunatha, Ujjini H.,Niyomrattanakit, Pornwaratt,Zhang, Liang,Goodwin, Michael,Dick, Thomas,Keller, Thomas H.,Dowd, Cynthia S.,Barry III, Clifton E.
experimental part, p. 1329 - 1344 (2009/12/07)
The (S)-2-nitro-6-substituted 6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines have been extensively explored for their potential use as new antituberculars based on their excellent bactericidal properties on aerobic whole cells of Mycobacterium tuberculosis. A
