112972-60-8

Basic information

• Product Name: BISUCABERIN
• Synonyms: BISUCABERIN;6,17-Dihydroxy-1,6,12,17-tetraazacyclodocosane-2,5,13,16-tetrone;Biscaberin
• CAS NO: 112972-60-8
• Molecular Formula: C18H32N4O6
• Molecular Weight: 400.47
• Mol File: 112972-60-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.162g/cm³
• Refractive Index: 1.495
• CAS DataBase Reference: BISUCABERIN(CAS DataBase Reference)
• NIST Chemistry Reference: BISUCABERIN(112972-60-8)
• EPA Substance Registry System: BISUCABERIN(112972-60-8)

Safety Data

• Hazardous Substances Data: 112972-60-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C18H32N4O6/c23-15-7-10-18(26)22(28)14-6-2-4-12-20-16(24)8-9-17(25)21(27)13-5-1-3-11-19-15/h27-28H,1-14H2,(H,19,23)(H,20,24)

Upstream product

• 128173-50-2 O-Benzyl-N-(tert-butoxycarbonyl)-N-(4-cyanobutyl)-hydroxylamine 
• 111-24-0 1,5-dibromo-pentane 
• 203189-78-0 N-hydroxy-N-succinyl-putrescine 
• 129245-26-7 6,17-bis(benzyloxy)-1,6,12,17-tetraazacyclodocosane-2,5,13,16-tetrone 
• 129245-25-6 21-amino-5,16-bis(benzyloxy)-4,12,15-trioxo-5,11,16-triazaheneicosanoic acid 
• 112139-59-0 O-benzyl-N-(4-cyanobutyl)-hydroxylamine 
• 129245-22-3 N-(4-cyanobutyl)-3-<<5-<(benzyloxy)-tert-butoxy-carbonylamino>pentyl>carbamoyl>-O-benzylpropionohydroxamic acid 
• 129245-23-4 N-(4-cyanobutyl)-3-<<5-<(benzyloxy)amino>pentyl>carbamoyl>-O-benzylpropionohydroxamic acid 
• 112139-60-3 N-(4-Cyanobutyl)-N-(benzyloxy)succinamic Acid 
• 129245-24-5 5,16-bis(benzyloxy)-20-cyano-4,12,15-trioxo-5,11,16-triazaeicosanoic acid 
• 129245-21-2 O-benzyl-N-(5-aminopentyl)-N-(tert-butoxycarbonyl)hydroxylamine 
• 6280-87-1 δ-chlorovaleronitrile 

Related news

Simultaneous biosynthesis of putrebactin, avaroferrin and BISUCABERIN (cas 112972-60-8) by Shewanella putrefaciens and characterisation of complexes with iron(III), molybdenum(VI) or chromium(V)07/27/2019

Cultures of Shewanella putrefaciens grown in medium containing 10 mM 1,4-diamino-2-butanone (DBO) as an inhibitor of ornithine decarboxylase and 10 mM 1,5-diaminopentane (cadaverine) showed the simultaneous biosynthesis of the macrocyclic dihydroxamic acids: putrebactin (pbH2), avaroferrin (avH2...detailed

Relevant articles and documents

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Convergent Synthesis of Macrocyclic and Linear Desferrioxamines

Polyhydroxamate desferrioxamines (DFO) are nontoxic siderophores endowed with high potential for development of therapeutic chelating agents. Herein, we report a modular and convergent strategy for diverse synthesis of macrocyclic and linear DFOs. The strategy employed orthogonally protected N-hydroxy-N-succinylcadaverine building blocks, which allowed bidirectional extension of the DFO structure. The efficiency of the new strategy was demonstrated by the total synthesis of 44-membered macrocyclic DFO-T1, as well as four related DFO compounds in 11–13 linear steps and 2.1 %–10 % overall yields. Comparison of the iron binding affinity of the DFOs revealed DFO-E as the best chelator.

THE TOTAL SYNTHESIS OF BISUCABERIN

The first total synthesis of 6,17-dihydroxy-1,6,12,17-tetraazacyclodocosane-2,5,13,16-tetrone (bisucaberin) is presented.The synthetic scheme employed in this study illustrates the utility of O-benzyl-N-(tert-butoxycarbonyl)-N-(4-cyanobutyl)hydroxylamine