128173-50-2Relevant articles and documents
Design, Synthesis and Evaluation of AdSS Bisubstrate Inhibitors
Tibrewal, Nidhi,Elliott, Gregory I.
supporting information, p. 2269 - 2272 (2020/09/17)
Many cancers lack the expression of methylthioadenosine phosphorylase (MTAP). These cancers require adenylosuccinate synthetase (AdSS) for nucleic acid synthesis. By inhibiting adenylosuccinate synthetase, we potentially have a new therapeutic agent. Bisubstrate inhibitors were synthesized and evaluated against purified AdSS. The best activity was obtained with adenosine bearing a four-carbon linker that connects the N-formyl-N-hydroxy moiety to the 6-position of the purine nucleoside.
The synthesis of tetrahydropyridopyrimidones as a new scaffold for HIV-1 integrase inhibitors
Kinzel, Olaf D.,Monteagudo, Edith,Muraglia, Ester,Orvieto, Federica,Pescatore, Giovanna,Ferreira, Maria del Rosario Rico,Rowley, Michael,Summa, Vincenzo
, p. 6552 - 6555 (2008/02/12)
An efficient synthesis of methyl 9-amino-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-2-carboxylate as a late stage intermediate for a new class of HIV-1 integrase inhibitors is described. After construction of the bicyclic core scaffold,
Total synthesis of the siderophore Danoxamine
Roosenberg II, John M.,Miller, Marvin J.
, p. 4833 - 4838 (2007/10/03)
The total synthesis of the linear trihydroxamate siderophore, Danoxamine, is described. Danoxamine is a siderophore component of the naturally occurring siderophore-drug conjugates Salmycin A-D. The synthesis of Danoxamine features a series of coupling re
