113010-09-6

Basic information

• Product Name: N,N-dimethyl-2-(1,2,3,9-tetrahydropyrrolo<2,1-b>quinazolin-3-yl)benzenamine; Vasicoline
• CAS NO: 113010-09-6
• Molecular Weight: 291.396
• Mol File: 113010-09-6.mol

Chemical Properties

• CAS DataBase Reference: N,N-dimethyl-2-(1,2,3,9-tetrahydropyrrolo<2,1-b>quinazolin-3-yl)benzenamine; Vasicoline(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-dimethyl-2-(1,2,3,9-tetrahydropyrrolo<2,1-b>quinazolin-3-yl)benzenamine; Vasicoline(113010-09-6)
• EPA Substance Registry System: N,N-dimethyl-2-(1,2,3,9-tetrahydropyrrolo<2,1-b>quinazolin-3-yl)benzenamine; Vasicoline(113010-09-6)

Safety Data

• Hazardous Substances Data: 113010-09-6(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 113010-17-6 2-(1,2,3,9-tetrahydropyrrolo<2,1-b>quinazolin-3-yl)benzenamine 

Downstream Products

• 113010-10-9 3-<2-(dimethylamino)phenyl>-2,3-dihydropyrrolo<2,1-b>quinazolin-9(1H)-one; Vasicolinone 

Relevant articles and documents

Rhodium-catalyzed direct C-H addition of 3,4-dihydroquinazolines to alkenes and their use in the total synthesis of vasicoline

The inter- and intramolecular couplings of unactivated alkenes to 3,4-dihydroquinazolines with a Rh(I) catalyst are reported. Coupling between olefins and NH-3,4-dihydroquinazoline was found to occur consecutively with heterocycle dehydrogenation in the p

Total Syntheses of Vasicoline and Vasicolinone

Bis-ortho-nitration of α-phenyl-N-(phenylmethyl)-γ-butanelactam (6) using acetyl nitrate followed by reduction and regiospecific dehydrative cyclization afforded quinazoline 12.The aniline moiety in 12 could be dimethylated by using aqueous formaldehyde a