1130206-80-2

Upstream product

• 1068-57-1 acetic acid hydrazide 
• 101-68-8 di(4-isocyanatophenyl)methane 

Downstream Products

• 1130206-85-7 4,4'-(methylenedi-4,1-phenylene)bis(2,4-dihydro-5-methyl-3H-1,2,4-triazol-3-one) 

Relevant academic research and scientific papers

Antioxidant evaluation of some semicarbazide, 1,2,4-triazolone and pyrazolone derivatives

1,2,4-Triazoles, pyrazoles and semicarbazides possessing heterocyclic ring 1-14 were synthesized as compounds with interesting pharmacological profiles. All were investigated in vitro for their antioxidant activity. Some compounds showed significant effect in the above assay. The most promising was a group of pyrazolone. The effect was dependent mainly on the substituent on the amide group. It was found that compounds 8 and 10 showed the highest antioxidant capacity comparable with the widely used reference, antioxidant 6-hydroxy-2,5,7,8- tetramethylchroman-2-carboxylic acid (Trolox).

Synthesis and RP HPLC studies of biologically active semicarbazides and their cyclic analogues 1,2,4-triazol-3-ones

The retention behaviour of semicarbazides and their cyclic analogues 1,2,4-triazol-3-ones, has been investigated by RP-8, RP-18 and IAM HPLC. The structures of new derivatives were proved by elemental analyses, IR, 1H NMR and 13C NMR

Synthesis, experimental and theoretical study on the structure of some semicarbazides with potential antibacterial activity

A series of 1,4-disubstituted semicarbazide and 4,4'-bis[1-substituted semicarbazide]diphenyl-methane derivatives were synthesized to explore their antibacterial activity. New compounds were characterized by elemental analysis and spectroscopic data. In order to find the tautomeric equilibrium for the molecules energy calculations for each possible tautomeric form of model compound 2, and for the most antibacterially active compound 7 in the investigated series, were calculated for the gas phase at the RHF/SCF/6-31G** level of theory.

Synthesis and antinociceptive activity of 4,4'-bis(1-substituted- semicarbazidyl)diphenylmethane and 4,4-bis(5-substituted-2,4-dihydro-3-oxo-3H-1, 2,4- triazol-4-yl)diphenylmethane derivatives

In the reaction of 4,4'-diphenylmethane diiso-cyanate with carboxylic acid hydrazides, 4,4'-bis(1- substituted-semicarbazidyl)diphenylmethane derivatives were obtained. Depending on their chemical nature, cyclization of these compounds in alkaline medium led to the formation of two groups of compounds: bis(2,4-dihy- dro-3H-1,2,4-triazol-3-one) derivatives or carboxylic acids. The pharmacological effects of the selected compounds on the central nervous system in mice were investigated. Strong antinociceptive properties of some derivatives, at a wide range of doses, were observed. Springer-Verlag 2010.

Synthesis, experimental and theoretical investigations of some new 4,4′-bis(3-substituted-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl)diphenylmethane derivatives

The 4,4′-bis(3-substituted-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl)diphenylmethane derivatives 3 were synthesized in the cyclization reaction of semicarbazide derivatives 2 in alkaline solution. The synthesized compounds were characterized by elemental an