1130206-84-6

Basic information

• Product Name: 4,4'-bis(1-phenylacetyl-semicarbazide)diphenylmethane
• Synonyms: 4,4'-bis(1-phenylacetyl-semicarbazide)diphenylmethane
• CAS NO: 1130206-84-6
• Molecular Weight: 550.617
• Mol File: 1130206-84-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4,4'-bis(1-phenylacetyl-semicarbazide)diphenylmethane(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4'-bis(1-phenylacetyl-semicarbazide)diphenylmethane(1130206-84-6)
• EPA Substance Registry System: 4,4'-bis(1-phenylacetyl-semicarbazide)diphenylmethane(1130206-84-6)

Safety Data

• Hazardous Substances Data: 1130206-84-6(Hazardous Substances Data)

Upstream product

• 937-39-3 2-phenylacetylhydrazine 
• 101-68-8 di(4-isocyanatophenyl)methane 
• 101-97-3 Ethyl 2-phenylethanoate 

Downstream Products

• 1130206-88-0 4,4'-bis(3-benzyl-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl)diphenylmethane 

Relevant articles and documents

Synthesis, experimental and theoretical study on the structure of some semicarbazides with potential antibacterial activity

A series of 1,4-disubstituted semicarbazide and 4,4'-bis[1-substituted semicarbazide]diphenyl-methane derivatives were synthesized to explore their antibacterial activity. New compounds were characterized by elemental analysis and spectroscopic data. In order to find the tautomeric equilibrium for the molecules energy calculations for each possible tautomeric form of model compound 2, and for the most antibacterially active compound 7 in the investigated series, were calculated for the gas phase at the RHF/SCF/6-31G** level of theory.

Synthesis and antinociceptive activity of 4,4'-bis(1-substituted- semicarbazidyl)diphenylmethane and 4,4-bis(5-substituted-2,4-dihydro-3-oxo-3H-1, 2,4- triazol-4-yl)diphenylmethane derivatives

In the reaction of 4,4'-diphenylmethane diiso-cyanate with carboxylic acid hydrazides, 4,4'-bis(1- substituted-semicarbazidyl)diphenylmethane derivatives were obtained. Depending on their chemical nature, cyclization of these compounds in alkaline medium led to the formation of two groups of compounds: bis(2,4-dihy- dro-3H-1,2,4-triazol-3-one) derivatives or carboxylic acids. The pharmacological effects of the selected compounds on the central nervous system in mice were investigated. Strong antinociceptive properties of some derivatives, at a wide range of doses, were observed. Springer-Verlag 2010.