1130608-93-3

Basic information

• Product Name: (R)-2-(2-fluoro-biphenyl-4-yl)-N-(3-{3-[4-(3-{3-[2-(2-fluoro-biphenyl-4-yl)-(R)-propionylamino]-propylamino}-propylamino)-3,6-dioxo-cyclohexa-1,4-dienylamino]-propylamino}-propyl)-propionamide
• Synonyms: (R)-2-(2-fluoro-biphenyl-4-yl)-N-(3-{3-[4-(3-{3-[2-(2-fluoro-biphenyl-4-yl)-(R)-propionylamino]-propylamino}-propylamino)-3,6-dioxo-cyclohexa-1,4-dienylamino]-propylamino}-propyl)-propionamide
• CAS NO: 1130608-93-3
• Molecular Weight: 819.007
• Mol File: 1130608-93-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-2-(2-fluoro-biphenyl-4-yl)-N-(3-{3-[4-(3-{3-[2-(2-fluoro-biphenyl-4-yl)-(R)-propionylamino]-propylamino}-propylamino)-3,6-dioxo-cyclohexa-1,4-dienylamino]-propylamino}-propyl)-propionamide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-(2-fluoro-biphenyl-4-yl)-N-(3-{3-[4-(3-{3-[2-(2-fluoro-biphenyl-4-yl)-(R)-propionylamino]-propylamino}-propylamino)-3,6-dioxo-cyclohexa-1,4-dienylamino]-propylamino}-propyl)-propionamide(1130608-93-3)
• EPA Substance Registry System: (R)-2-(2-fluoro-biphenyl-4-yl)-N-(3-{3-[4-(3-{3-[2-(2-fluoro-biphenyl-4-yl)-(R)-propionylamino]-propylamino}-propylamino)-3,6-dioxo-cyclohexa-1,4-dienylamino]-propylamino}-propyl)-propionamide(1130608-93-3)

Safety Data

• Hazardous Substances Data: 1130608-93-3(Hazardous Substances Data)

Upstream product

• 122248-82-2 N-(3-aminopropyl)-N,N'-bis(tert-butoxycarbonyl)propane-1,3-diamine 
• 5104-49-4 (R)-flurbiprofen 
• 1130609-30-1 (R)-(3-tert-butoxycarbonylamino-propyl)-{3-[2-(2-fluoro-biphenyl-4-yl)-propionylamino]-propyl}-carbamic acid tert-butyl ester 
• 1130609-32-3 (R)-N-[3-(3-amino-propylamino)-propyl]-2-(2-fluoro-biphenyl-4-yl)-propionamide 
• 3117-03-1 2,5-dimethoxyquinone 

Relevant articles and documents

Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer's disease

The anti-amyloid properties shared by several quinones inspired the design of a new series of hybrids derived from the multi-target drug candidate memoquin (1). The hybrids consist of a central benzoquinone core and a fragment taken from non-steroidal anti-inflammatory drugs, connected through polyamine linkers. The new hybrids retain the potent anti-aggregating activity of the parent 1, while exhibiting micromolar AChE inhibitory activities. Remarkably, 2, 4, (R)-6 and (S)-6 were Aβ aggregation inhibitors even more potent than 1. The balanced amyloid/cholinesterase inhibitory profile is an added value that makes the present series of compounds promising leads against Alzheimer's disease.