1130682-67-5

Upstream product

• 1130681-84-3 2-acetoxy-N-(3-methoxyphenyl)-N-propylacetamide 

Downstream Products

• 1318074-95-1 (2R,3R,5aS,10aR)-6'-methoxy-3-phenyl-1'-propyl-5a,6,7,8-tetrahydro-1H-spiro[dipyrrolo[1,2-a:1'2'-d]pyrazine-2,3'-indoline]-2',5,10(3H,10aH)-trione 
• 1318074-94-0 (2S,3S,5aS,10aS)-6'-methoxy-3-phenyl-1'-propyl-5a,6,7,8-tetrahydro-1H-spiro[dipyrrolo[1,2-a:1'2'-d]pyrazine-2,3'-indoline]-2',5,10(3H,10aH)-trione 
• 1318074-91-7 (2'R,5'R,3R)-6-methoxy-2-oxo-2'-phenyl-1-propyl-1'-[1-(3,3,3-trichloroethoxycarbonyl)-pyrrolidine-2S-carbonyl]-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid methyl ester 
• 1318074-90-6 (2'S,5'S,3S)-6-methoxy-2-oxo-2'-phenyl-1-propyl-1'-[1-(3,3,3-trichloroethoxycarbonyl)-pyrrolidine-2S-carbonyl]-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Exploiting Sm(ii) and Sm(iii) in SmI2-initiated reaction cascades: Application in a tag removal-cyclisation approach to spirooxindole scaffolds

A tag removal-cyclisation sequence is described that is initiated by reduction using a Sm(ii) species and completed by a Sm(iii) Lewis acid that is formed in an earlier stage. Therefore, the reaction cascade utilises both oxidation states of a samarium reagent in discrete steps and allows access to privileged, pyrrolidinyl-spirooxindole scaffolds and analogues inspired by the anti-cancer natural product spirotryprostatin A. The Royal Society of Chemistry 2011.

Formation of N-heterocycles by the reaction of thiols with glyoxamides: Exploring a connective Pummerer-type cyclisation

The reaction of thiols with glyoxamides provides a convenient method for the generation of thionium ions and the initiation of Pummerer-type reactions. When the glyoxamides contain tethered aromatic nucleophiles, N-heterocycles are formed by a thionium ion cyclisation. The scope and mechanism of the connective Pummerer-type process has been investigated using a range of thiols, Lewis acids and both mono- and bis-glyoxamides. The utility of the process has been illustrated in a synthesis of the indoloquinoline natural product, neocryptolepine. The Royal Society of Chemistry 2009.