1318074-91-7

Upstream product

• 847550-38-3 3-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecylsulfanyl)-6-methoxy-1-propyl-1,3-dihydroindole-2-one 
• 1130682-67-5 2-hydroxy-N-(3-methoxyphenyl)-N-propylacetamide 
• 1130681-84-3 2-acetoxy-N-(3-methoxyphenyl)-N-propylacetamide 
• 1318074-63-3 3-(4-chlorobut-2-enyl)-3-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecylsulfanyl)-6-methoxy-1-propyl-1,3-dihydroindol-2-one 
• 127940-23-2 N-2,2,2-trichloroethoxycarbonyl-L-prolinyl chloride 
• 780-25-6 N-benzylidene benzylamine 

Downstream Products

• 1318074-95-1 (2R,3R,5aS,10aR)-6'-methoxy-3-phenyl-1'-propyl-5a,6,7,8-tetrahydro-1H-spiro[dipyrrolo[1,2-a:1'2'-d]pyrazine-2,3'-indoline]-2',5,10(3H,10aH)-trione 

Relevant academic research and scientific papers

Exploiting Sm(ii) and Sm(iii) in SmI2-initiated reaction cascades: Application in a tag removal-cyclisation approach to spirooxindole scaffolds

A tag removal-cyclisation sequence is described that is initiated by reduction using a Sm(ii) species and completed by a Sm(iii) Lewis acid that is formed in an earlier stage. Therefore, the reaction cascade utilises both oxidation states of a samarium reagent in discrete steps and allows access to privileged, pyrrolidinyl-spirooxindole scaffolds and analogues inspired by the anti-cancer natural product spirotryprostatin A. The Royal Society of Chemistry 2011.