1130965-92-2Relevant academic research and scientific papers
Copper-catalyzed oxidative C-H, N-H coupling of azoles and thiophenes
Mitsuda, Shinobu,Fujiwara, Taiki,Kimigafukuro, Katsuyoshi,Monguchi, Daiki,Mori, Atsunori
experimental part, p. 3585 - 3590 (2012/06/30)
CH, NH coupling of azole and thiophene derivatives takes place in the presence of a catalytic amount of Cu(OAc)2 and an additive. The reaction of azoles smoothly occurs with several amines and amides catalyzed by 20 mol % of Cu(OAc)2-2PPh3 and 4 equiv of NaOAc under O2 or in the presence of Ag2CO3 under N 2. The coupling reaction leads to a facile synthesis of a N-substituted analogue of 2,5-diarylthiazole, which shows photoluminescent properties with extended π-conjugation. Spectroscopic characteristics of the obtained thiazole derivatives are discussed by measurements of UV-vis absorption and photoluminescent spectra. Under the reaction conditions using Ag 2CO3 as an additive and Cu(OAc)2-2PPh 3 as a catalyst, thiophene derivatives also react with 2-pyrrolidone to undergo CH, NH amidation.
Direct amination of azoles via catalytic C-H, N-H Coupling
Monguchi, Daiki,Fujiwara, Taiki,Furukawa, Hirotoshi,Mori, Atsunori
supporting information; experimental part, p. 1607 - 1610 (2009/09/06)
C-H, N-H Coupling of azoles takes place with several amines in the presence of a copper catalyst to undergo amination at the 2-position. The reaction of benzothiazole with N-methylaniline in the presence of sodium acetate and 20 mol % Cu(0Ac)2
