1131-35-7

Basic information

• Product Name: 4,6-Pteridinedione,2-amino-1,5,7,8-tetrahydro-(8CI,9CI)
• Synonyms: 4,6-Pteridinedione,2-amino-1,5,7,8-tetrahydro-(8CI,9CI);2-AMINO-1,5,7,8-TETRAHYDROPTERIDINE-4,6-DIONE;7,8,DIHYDROXANTHOPTERIN;4,6-Pteridinedione, 2-aMino-3,5,7,8-tetrahydro-
• CAS NO: 1131-35-7
• Molecular Formula: C₆H₇N₅O₂
• Molecular Weight: 181.15
• Product Categories: PIPERIDINE
• Mol File: 1131-35-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 2.2g/cm³
• Refractive Index: 1.991
• PKA: 10.56±0.20(Predicted)
• CAS DataBase Reference: 4,6-Pteridinedione,2-amino-1,5,7,8-tetrahydro-(8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-Pteridinedione,2-amino-1,5,7,8-tetrahydro-(8CI,9CI)(1131-35-7)
• EPA Substance Registry System: 4,6-Pteridinedione,2-amino-1,5,7,8-tetrahydro-(8CI,9CI)(1131-35-7)

Safety Data

• Hazardous Substances Data: 1131-35-7(Hazardous Substances Data)

Usage

General Description

4,6-Pteridinedione,2-amino-1,5,7,8-tetrahydro-(8CI,9CI) is a chemical compound with the molecular formula C7H8N4O2. It is a pteridine derivative that has potential biological and pharmacological applications. 4,6-Pteridinedione,2-amino-1,5,7,8-tetrahydro-(8CI,9CI) has been studied for its potential use in the treatment of various neurological disorders and as a precursor in the synthesis of certain pharmaceuticals. It is also known for its antioxidant properties and its ability to scavenge free radicals. Additionally, it has been investigated for its potential role in the development of new therapeutic agents for conditions such as cancer and inflammatory diseases. Overall, 4,6-Pteridinedione,2-amino-1,5,7,8-tetrahydro-(8CI,9CI) has shown promise as a versatile and valuable compound with a wide range of potential applications.

InChI:InChI=1/C6H7N5O2/c7-6-10-4-3(5(13)11-6)9-2(12)1-8-4/h1H2,(H,9,12)(H4,7,8,10,11,13)

Upstream product

• 1194-21-4 6-chloroisocytosine 
• 492-11-5 leucopterin 
• 1218-98-0 dihydro-7,8-D-neopterine 
• 6779-87-9 7,8-dihydro-L-biopterin 
• 4033-27-6 (S)-2-{4-[(2-Amino-4-oxo-3,4,7,8-tetrahydro-pteridin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid 
• 13214-44-3 6-formyl-7,8-dihydropterin 
• 119-44-8 xanthopterin 

Downstream Products

• 119-44-8 xanthopterin 

Relevant articles and documents

Stability of 7,8-dihydropterins in air-equilibrated aqueous solutions

6-Substituted 7,8-dihydropterins (=2-amino-7,8-dihydropteridin-4(1H)-ones) are heterocyclic compounds that occur in a wide range of living systems and participate in relevant biological functions. In airequilibrated aqueous solutions, these compounds react with dissolved O2 (autooxidation). The rates of these reactions as well as the products formed strongly depend on the chemical structure of the substituents. 7,8-Dihydro-6-methylpterin and 7,8-dihydro-6,7-dimethylpterin that bear electron-donor groups as substituents are the most reactive derivatives and undergo oxidation of the pterin moiety to yield the corresponding oxidized derivatives (6-methylpterin and 6,7-dimethylpterin, resp.). The oxidations of 7,8-dihydrobiopterin, 7,8-dihydroneopterin, and 7,8-dihydrofolic acid are slower, and they yield 7,8-dihydroxanthopterin as the main product. 7,8-Dihydroxanthopterin, 6-formyl-7,8-dihydropterin, and sepiapterin are rather stable, and their consumption in air-equilibrated solutions is negligible for several days. The pseudo-first-order rate constants of the reactions between these compounds and O2 at 25° and 40° are reported. The biological implications of the results obtained are also discussed.

The preparation of xanthopterin.

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Determination of Pterins in Biological Samples by Liquid Chromatography/Electrochemistry with a Dual-Electrode Detector

The pterins are a family of compounds that are currently of great interest in medicine and biology.Biopterin, in its reduced form, serves as the cofactor to the enzyme which catalyze the rate-limiting reactions in the biosynthesis of the catecholamines and serotonin.As such, it may serve a role in the regulation of the neurotransmitters.Abnormal pterin concentrations have been observed in the urine and serum of patiens with several diseases.No currently available analytical method is totally satisfactory for the determination of pterins in biological samples.They lack either specificity or the ability to detect both the oxidzed and reduced forms of the pterins.Liquid chromatography/electrochemistry (LCEC) using a dual-electrode detector can overcome both of these problems.A method has been developed that is capable of determining several pterin species and their various oxidation states in biological samples.The dual-electrode detector used in a parallel-adjacent configuration is also capable of enhancing peak identity assignments and selectively determining easily oxidized compounds in the presence of harder to oxidize compounds.