1131-35-7

Usage

Uses

Used in Pharmaceutical Synthesis:
4,6-Pteridinedione,2-amino-1,5,7,8-tetrahydro-(8CI,9CI) is used as a precursor in the synthesis of certain pharmaceuticals, contributing to the development of new drugs with potential therapeutic benefits.
Used in Neurological Disorder Treatment:
In the healthcare industry, 4,6-Pteridinedione,2-amino-1,5,7,8-tetrahydro-(8CI,9CI) is used as a potential treatment for various neurological disorders, leveraging its pharmacological properties to address these conditions.
Used in Antioxidant and Free Radical Scavenging Applications:
4,6-Pteridinedione,2-amino-1,5,7,8-tetrahydro-(8CI,9CI) is utilized for its antioxidant properties and its ability to scavenge free radicals, which can be beneficial in various health and medical applications to protect against oxidative stress and related conditions.
Used in Cancer and Inflammatory Disease Research:
In the field of medical research, 4,6-Pteridinedione,2-amino-1,5,7,8-tetrahydro-(8CI,9CI) is used in the development of new therapeutic agents for conditions such as cancer and inflammatory diseases, exploring its potential to contribute to novel treatment strategies.

InChI:InChI=1/C6H7N5O2/c7-6-10-4-3(5(13)11-6)9-2(12)1-8-4/h1H2,(H,9,12)(H4,7,8,10,11,13)

Upstream product

• 1218-98-0 dihydro-7,8-D-neopterine 
• 6779-87-9 7,8-dihydro-L-biopterin 
• 4033-27-6 (S)-2-{4-[(2-Amino-4-oxo-3,4,7,8-tetrahydro-pteridin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid 
• 119-44-8 xanthopterin 
• 13214-44-3 6-formyl-7,8-dihydropterin 
• 492-11-5 leucopterin 
• 1194-21-4 6-chloroisocytosine 

Downstream Products

• 119-44-8 xanthopterin 

Relevant academic research and scientific papers

Stability of 7,8-dihydropterins in air-equilibrated aqueous solutions

6-Substituted 7,8-dihydropterins (=2-amino-7,8-dihydropteridin-4(1H)-ones) are heterocyclic compounds that occur in a wide range of living systems and participate in relevant biological functions. In airequilibrated aqueous solutions, these compounds react with dissolved O2 (autooxidation). The rates of these reactions as well as the products formed strongly depend on the chemical structure of the substituents. 7,8-Dihydro-6-methylpterin and 7,8-dihydro-6,7-dimethylpterin that bear electron-donor groups as substituents are the most reactive derivatives and undergo oxidation of the pterin moiety to yield the corresponding oxidized derivatives (6-methylpterin and 6,7-dimethylpterin, resp.). The oxidations of 7,8-dihydrobiopterin, 7,8-dihydroneopterin, and 7,8-dihydrofolic acid are slower, and they yield 7,8-dihydroxanthopterin as the main product. 7,8-Dihydroxanthopterin, 6-formyl-7,8-dihydropterin, and sepiapterin are rather stable, and their consumption in air-equilibrated solutions is negligible for several days. The pseudo-first-order rate constants of the reactions between these compounds and O2 at 25° and 40° are reported. The biological implications of the results obtained are also discussed.

Reaction between 7,8-dihydropterins and hydrogen peroxide under physiological conditions

In vitiligo, a common skin disorder that produces white patches of depigmentation, 7,8-dihydropterins accumulate in the presence of high concentration of H2O2. In this work, we present a study of the reaction between 7,8-dihydropterins and H2O2. The rate of the reaction, as well as the products formed, strongly depend on the chemical structure of the substituents. Electron-donor groups as substituents are the most reactive derivatives and undergo oxidation of the pterin moiety. The corresponding bimolecular rate constants at 37 °C in neutral aqueous solutions are reported. The biological implications of the results obtained are also discussed.

Determination of Pterins in Biological Samples by Liquid Chromatography/Electrochemistry with a Dual-Electrode Detector

The pterins are a family of compounds that are currently of great interest in medicine and biology.Biopterin, in its reduced form, serves as the cofactor to the enzyme which catalyze the rate-limiting reactions in the biosynthesis of the catecholamines and serotonin.As such, it may serve a role in the regulation of the neurotransmitters.Abnormal pterin concentrations have been observed in the urine and serum of patiens with several diseases.No currently available analytical method is totally satisfactory for the determination of pterins in biological samples.They lack either specificity or the ability to detect both the oxidzed and reduced forms of the pterins.Liquid chromatography/electrochemistry (LCEC) using a dual-electrode detector can overcome both of these problems.A method has been developed that is capable of determining several pterin species and their various oxidation states in biological samples.The dual-electrode detector used in a parallel-adjacent configuration is also capable of enhancing peak identity assignments and selectively determining easily oxidized compounds in the presence of harder to oxidize compounds.