1218-98-0

Usage

Uses

Used in Pharmaceutical Industry:
7,8-Dihydroneopterin is used as a research compound for studying the biosynthesis of biopterin and its role in various biological processes. It is particularly useful in understanding the metabolic pathways and enzyme functions related to biopterin synthesis.
Used in Diagnostic Applications:
7,8-Dihydroneopterin can be used as a diagnostic marker to monitor the levels of biopterin and neopterin in biological samples. This can help in the identification and monitoring of certain genetic disorders and conditions that affect the metabolism of neurotransmitters.
Used in Biochemical Research:
7,8-Dihydroneopterin is used as a biochemical research tool to study the mechanisms of enzyme-catalyzed reactions involving biopterin and its precursors. It can also be used to investigate the role of biopterin in various cellular processes and its potential as a therapeutic target for certain diseases.

InChI:InChI=1/C9H13N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h4,6,15-17H,1-2H2,(H4,10,11,13,14,18)/t4-,6+/m1/s1

Upstream product

• 2009-64-5 Neopterin 
• 86-01-1 Guanosine 5'-triphosphate 

Downstream Products

• 3672-03-5 7,8-dihydro-6-(hydroxymethyl)pterin 
• 141-46-8 Glycolaldehyde 
• 1131-35-7 7,8-dihydroxanthopterin 
• 13214-44-3 6-formyl-7,8-dihydropterin 
• 4033-27-6 (S)-2-{4-[(2-Amino-4-oxo-3,4,7,8-tetrahydro-pteridin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid 
• 135-16-0 (6S,S)-5,6,7,8-tetrahydrofolic acid 
• 3545-84-4 6-hydroxymethyl-7,8-dihydro-pterin pyrophosphate 

Related news

Effect of 7,8-DIHYDRONEOPTERIN (cas 1218-98-0) mediated CD36 down regulation and oxidant scavenging on oxidised low-density lipoprotein induced cell death in human macrophages07/20/2019

The role of CD36 in oxidised low-density lipoprotein (oxLDL) mediated cell death was examined by down regulating the receptor level with the macrophage generated antioxidant 7,8‐dihydroneopterin. Down regulation of CD36 protein levels in human monocyte derived macrophages by 7,8-dihydroneopteri...detailed

Relevant academic research and scientific papers

Synthesis of 5,6,7,8-Tetrahdro-D-neopterine tripolyphosphate. Attempt to Interpret the Biosynthesis of L-Sepiapterine

The synthesis was achieved by phosphorylation of tetrahydro-5,6,7,8-D-neopterine with polyphosphoric acid.The product is sensitive to light, moisture and oxidation like the other tetrahydropterines.After oxidation in aqueous solution, D,L-sepiapterine was isolated in 5percent yield.The oxidation of non-phosphorilated tetrahydro-5,6,7,8-D-neopterine under the same conditions led to D-sepiapterine without inversion of the configuration.These findings were used to give a tentative explanation for the biosynthesis of natural L-sepiapterine from the D-neopterine.

Chemoenzymatic Assembly of Isotopically Labeled Folates

Pterin-containing natural products have diverse functions in life, but an efficient and easy scheme for their in vitro synthesis is not available. Here we report a chemoenzymatic 14-step, one-pot synthesis that can be used to generate 13C- and 15N-labeled dihydrofolates (H2F) from glucose, guanine, and p-aminobenzoyl-l-glutamic acid. This synthesis stands out from previous approaches to produce H2F in that the average yield of each step is >91% and it requires only a single purification step. The use of a one-pot reaction allowed us to overcome potential problems with individual steps during the synthesis. The availability of labeled dihydrofolates allowed the measurement of heavy-atom isotope effects for the reaction catalyzed by the drug target dihydrofolate reductase and established that protonation at N5 of H2F and hydride transfer to C6 occur in a stepwise mechanism. This chemoenzymatic pterin synthesis can be applied to the efficient production of other folates and a range of other natural compounds with applications in nutritional, medical, and cell-biological research.