113102-19-5Relevant articles and documents
Synthesis and biological activity of some derivatives of rifamycin P
Cavalleri,Turconi,Tamborini,Occelli,Cietto,Pallanza,Scotti,Berti,Romano,Parenti
, p. 1470 - 1476 (2007/10/02)
A series of derivatives of rifamycin P, an antibiotic produced by fermentation of a mutant strain of Nocardia mediterranea or by chemical modification of rifamycin S, have been prepared. The structures of these compounds were determined by 1H NMR, IR, UV, and LC/MS. Their in vitro and in vivo antibacterial activities in comparison with rifampicin and two other rifamycins under investigation were evaluated. The derivatives were more active than rifamycin P against Mycobacterium avium complex and other slowly and rapidly growing nontuberculous mycobacteria which frequently cause systemic infection in patients with AIDS. 2'-(Diethylamino)rifamycin P (P/DEA) appears suitable for further investigation.
