113106-16-4Relevant articles and documents
Antitumour polycyclic acridines. Part 9. Synthesis of 7H-pyrido[4,3,2-kl]acridines with basic side chains
Ellis, Michael J.,Stevens, Malcolm F.G.
, p. 3174 - 3179 (2007/10/03)
[3 + 2] Cycloaddition of 3-(dialkylamino)-1-triphenylphosphoranylidenepropan-2-ones and 9-azidoacridine affords 9-[5-(dialkylaminomethyl)-1H-1,2,3-triazol-1-yl]acridines. Graebe-Ullmann thermolysis of the triazoles has been guided by differential scanning calorimetry to predict the optimum temperature for nitrogen extrusion. Boiling diphenyl ether (bp 259°C) is a suitable solvent to convert the triazolylacridines to 2-(dialkylaminomethyl)-7H-pyrido[4,3,2-kl]acridines.