1131215-88-7

Basic information

• Product Name: 4-(2-{2-[(2R)-2-methylpyrrolidin-1-yl]ethyl}-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)benzonitrile hydrochloride
• Synonyms: 4-(2-{2-[(2R)-2-methylpyrrolidin-1-yl]ethyl}-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)benzonitrile hydrochloride
• CAS NO: 1131215-88-7
• Molecular Weight: 395.932
• Mol File: 1131215-88-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(2-{2-[(2R)-2-methylpyrrolidin-1-yl]ethyl}-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)benzonitrile hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-{2-[(2R)-2-methylpyrrolidin-1-yl]ethyl}-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)benzonitrile hydrochloride(1131215-88-7)
• EPA Substance Registry System: 4-(2-{2-[(2R)-2-methylpyrrolidin-1-yl]ethyl}-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)benzonitrile hydrochloride(1131215-88-7)

Safety Data

• Hazardous Substances Data: 1131215-88-7(Hazardous Substances Data)

Upstream product

• 15115-60-3 4-bromo-2,3-dihydroinden-1-one 
• 1131222-71-3 (R)-5-Bromo-2-[2-(2-methylpyrrolidin-1-yl)ethyl]-3,4-dihydroisoquinolin-1(2H)-one 
• 126747-14-6 4-cyanophenylboronic acid 
• 1131222-63-3 2-(5-bromo-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)acetaldehyde 
• 1131222-53-1 2-allyl-5-bromo-3,4-dihydroisoquinolin-1(2H)-one 
• 1109230-25-2 5-bromo-1,2,3,4-tetrahydroisoquinolin-1-one 

Relevant articles and documents

2-(Pyrrolidin-1-yl)ethyl-3,4-dihydroisoquinolin-1(2H)-one derivatives as potent and selective histamine-3 receptor antagonists

On the basis of the previously reported benzimidazole 1,3′- bipyrrolidine benzamides (1), a new class of 2-(pyrrolidin-1-yl)ethyl-3,4- dihydroisoquinolin-1(2H)-one derivatives (3-50) were synthesized and evaluated as potent H3 receptor antagonists. In particular, compound 39 exhibited potent in vitro binding and functional activities at the H3 receptor, good selectivities against other neurotransmitter receptors and ion channels, acceptable pharmacokinetic properties, and a favorable in vivo profile.