113137-29-4

Basic information

• Product Name: N-(4-CHLORO-6-METHOXYPHENYL)-2,2-DIMETHYLPROPANAMIDE
• Synonyms: N-(4-CHLORO-6-METHOXYPHENYL)-2,2-DIMETHYLPROPANAMIDE;4'-CHLORO-2,2-DIMETHYL-2'-METHOXYPROPIONANILIDE;N-(4-Chloro-2-methoxyphenyl)pivalamide
• CAS NO: 113137-29-4
• Molecular Formula: C₁₂H₁₆ClNO₂
• Molecular Weight: 241.71394
• Product Categories: Aromatics Compounds;Aromatics
• Mol File: 113137-29-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 359.2°C at 760 mmHg
• Flash Point: 171°C
• Appearance: /
• Density: 1.161g/cm³
• Vapor Pressure: 2.42E-05mmHg at 25°C
• Refractive Index: 1.546
• Solubility: Chloroform, Dichloromethane, Dimethyl Sulfoxide, Ethyl Acetate, Methanol
• CAS DataBase Reference: N-(4-CHLORO-6-METHOXYPHENYL)-2,2-DIMETHYLPROPANAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-CHLORO-6-METHOXYPHENYL)-2,2-DIMETHYLPROPANAMIDE(113137-29-4)
• EPA Substance Registry System: N-(4-CHLORO-6-METHOXYPHENYL)-2,2-DIMETHYLPROPANAMIDE(113137-29-4)

Safety Data

• Hazardous Substances Data: 113137-29-4(Hazardous Substances Data)

Usage

Chemical Properties

Brown Solid

Uses

N-(4-Chloro-6-methoxyphenyl)-2,2-dimethylpropanamide (cas# 113137-29-4) is a compound useful in organic synthesis.

InChI:InChI=1/C12H16ClNO2/c1-12(2,3)11(15)14-9-6-5-8(13)7-10(9)16-4/h5-7H,1-4H3,(H,14,15)

Upstream product

• 861299-14-1 4-chloro-2-methoxyaniline hydrochloride 
• 3282-30-2 pivaloyl chloride 
• 93-50-5 4-chloro-o-anisidine 
• 6627-53-8 1-chloro-3-methoxy-4-nitrobenzene 
• 497-19-8 sodium carbonate 

Downstream Products

• 922162-50-3 N-(4-chloro-2-[hydroxy(2-methoxyphenyl)methyl]-6-methoxyphenyl)-2,2-dimethylpropanamide 
• 922162-51-4 (5-chloro-2-[(2,2-dimethylpropyl)amino]-3-methoxyphenyl)(2-methoxyphenyl)methanol 
• 922162-52-5 (R)-(5-chloro-2-[(2,2-dimethylpropyl)amino]-3-methoxyphenyl)(2-methoxyphenyl)methanol 
• 922162-53-6 (S)-(5-chloro-2-[(2,2-dimethylpropyl)amino]-3-methoxyphenyl)(2-methoxyphenyl)methanol 
• 922160-86-9 methyl 4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)-methyl]-6-methoxyphenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoate 
• 922160-87-0 4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)methyl]-6-methoxyphenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoic acid 
• 922160-88-1 ethyl 1-(4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)-methyl]-6-methoxyphenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-4-carboxylate 
• 922160-89-2 1-(4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)-methyl]-6-methoxyphenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-4-carboxylic acid 
• 922160-92-7 ethyl (3S)-1-(4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)methyl]-6-methoxyphenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate 
• 922160-93-8 (3S)-1-(4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)methyl]-6-methoxyphenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylic acid 
• 922160-90-5 ethyl (3R)-1-(4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)methyl]-6-methoxyphenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate 
• 922160-91-6 (3R)-1-(4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)methyl]-6-methoxyphenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylic acid 
• 922160-99-4 methyl 4-[(4-chloro-2-[(R)-hydroxy(2-methoxyphenyl)methyl]-6-methoxyphenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoate 
• 922161-00-0 4-[(4-chloro-2-[(R)-hydroxy(2-methoxyphenyl)methyl]-6-methoxyphenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoic acid 

Relevant articles and documents

Discovery of atrop fixed alkoxy-aminobenzhydrol derivatives: Novel, highly potent and orally efficacious squalene synthase inhibitors

We have recently reported the discovery of the new benzhydrol template, which has a highly potent inhibitory activity for squalene synthase, as typified by compound 1 (SSI IC50 = 0.85 nM). However, it was composed of a pair of easy rotatable at

Synthesis and biological activities of potential metabolites of the non-nucleoside reverse transcriptase inhibitor efavirenz

Studies on the biotransformation of the clinically important non-nucleoside reverse transcriptase inhibitor efavirenz have shown that oxidation and secondary conjugation are important components of the processing of this molecule in vivo. We have synthesized metabolites of efavirenz to confirm their structure and to evaluate their activity as antivirals.

Synthesis and evaluation of analogs of Efavirenz (SUSTIVA(TM)) as HIV-1 reverse transcriptase inhibitors

Efavirenz (SUSTIVA(TM)) is a potent non-nucleoside reverse transcriptase inhibitor. Due to the observation of breakthrough mutations of the reverse transcriptase enzyme during Efavirenz therapy, we sought to develop an optimized second generation series. To that end, SAR of the substituents on the aromatic ring was undertaken and the results are summarized here. The 5,6-difluoro (4f) and the 6-methoxy (4m) substituted benzoxazinones were determined to be equipotent, and as a result such substitution patterns will be incorporated in second generation scaffolds.