1131376-40-3Relevant academic research and scientific papers
Regioselectivity of larock indole synthesis using functionalized alkynes
Sugino, Kumi,Yoshimura, Hiroshi,Nishikawa, Toshio,Isobe, Minoru
, p. 2092 - 2102 (2008/12/23)
Regioselectivity of Larock indole synthesis, a palladium-catalyzed heteroannulation between o-iodoaniline and internal acetylene, was estimated using acetylenes substituted with ester and/or Boc-protected amine at the homopropargylic position and with perbenzyl- and unprotected glucose. Low to moderate regioselectivities were observed in all the cases, indicating these functional groups do not exert good directing effects, in the Larock indole synthesis.
