1131625-97-2Relevant academic research and scientific papers
Synthesis of activated cyclopropanes by an MIRC strategy: An enantioselective organocatalytic approach to spirocyclopropanes
Russo, Alessio,Meninno, Sara,Tedesco, Consiglia,Lattanzi, Alessandra
scheme or table, p. 5096 - 5103 (2011/10/12)
An efficient cyclopropanation, by a Michael-initiated ring-closing (MIRC) reaction of 2-arylidene-1,3-indandiones and 2-arylidene malononitriles, has been developed by using different α-monohalogenated methylene active compounds with triethylamine. The first enantioselective cyclopropanation to spirocyclopropanes derived by the reaction of 2-arylidene-1,3-indandiones and dimethyl bromomalonate with a commercially available α,α-L- diarylprolinol as the organocatalyst and K2CO3 as the additive has been accomplished. The spirocyclopropanes were isolated in high yield and up to 85% ee. Notably, the asymmetric one-pot sequential approach to spirocyclopropanes proved to be a feasible process. A simple triethylamine-promoted domino cyclopropanation of 2-arylidene-1,3-indandiones and 2-arylidenemalononitriles with α-monohalogenated methylene-active compounds has been efficiently developed. Spirocyclopropanes derived from 2-arylidene-1,3-indandiones were synthesized with up to 85% ee by using dimethyl bromomalonate and α,α-L-diarylprolinol/K2CO3 system. Copyright
Investigation of reactions of the organozinc reagents prepared from zinc and dialkyl dibromomalonates with the derivatives of 2-arylmethyleneindan-1,3- dione and 5-arylmethylene-2,2-dimethyl-1,3-dioxane-4,6-dione
Shchepin,Stepanyan,Silaichev
, p. 929 - 932 (2008/12/20)
Organozinc compounds prepared from dialkyl dibromomalonates and zinc react with 2-arylmethyl-eneindan-4,6-diones, 5-arylmethylene-2,2-dimethyl-1,3-dioxane- 4,6-diones, as well as with 2-[4-(1,3-dioxoindan-2-ylidenemethyl)phenyl] methyleneindan-1,3-dione a
