5381-33-9

Basic information

• Product Name: 2-benzylidene-1H-indene-1,3(2H)-dione
• Synonyms: 1H-Indene-1,3(2H)-dione, 2-(phenylmethylene)-; 2-Benzylidene-1H-indene-1,3(2H)-dione
• CAS NO: 5381-33-9
• Molecular Formula: C₁₆H₁₀O₂
• Molecular Weight: 234.2494
• Mol File: 5381-33-9.mol
• Article Data: 67

Chemical Properties

• Boiling Point: 432.2°C at 760 mmHg
• Flash Point: 161.4°C
• Density: 1.306g/cm³
• Vapor Pressure: 1.13E-07mmHg at 25°C
• Refractive Index: 1.7
• CAS DataBase Reference: 2-benzylidene-1H-indene-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-benzylidene-1H-indene-1,3(2H)-dione(5381-33-9)
• EPA Substance Registry System: 2-benzylidene-1H-indene-1,3(2H)-dione(5381-33-9)

Safety Data

• Hazardous Substances Data: 5381-33-9(Hazardous Substances Data)

Usage

General Description

2-benzylidene-1H-indene-1,3(2H)-dione, also known as α-Benzylideneindan-1-one, is an organic compound with the molecular formula C18H14O2. It is a yellow crystalline solid that is commonly used as a dye intermediate and in the production of pharmaceuticals. It is also used in the synthesis of various organic compounds due to its versatile reactivity. 2-benzylidene-1H-indene-1,3(2H)-dione is known for its strong aromatic and sweet odor and is often used as a flavoring agent in the food industry. Additionally, it has been studied for its potential biological activities, including its potential as an anti-cancer agent.

Upstream product

• 110-89-4 piperidine 
• 606-23-5 1H-indene-1,3(2H)-dione 
• 64-17-5 ethanol 
• 100-52-7 benzaldehyde 
• 861361-49-1 2-(α-hydroxy-benzyl)-indan-1,3-dione 
• 108-88-3 toluene 
• 90787-01-2 1,2-dimethyl-3-ethoxycarbonyl-4-phenyl-5-oxo-4,5-dihydro-1H-indeno<1,2-b>pyridine 
• 7664-93-9 sulfuric acid 
• 64-19-7 acetic acid 
• 98635-30-4 C₂₅H₁₅O₄^(1-) 
• 71-43-2 benzene 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 38846-64-9 2-ethynylbenzaldehyde 
• 84-66-2 Diethyl phthalate 

Downstream Products

• 19419-23-9 2,2'-phenylmethylene-bis(5,5-dimethylcyclohexane-1,3-dione) 
• 824428-86-6 2,2''-benzylidene-bis-[1,2']biindenylidene-3,1',3'-trione 
• 26576-79-4 2-Methyl-3-ethoxycarbonyl-4-phenyl-5-oxo-4,5-dihydro-1H-indeno<1,2-b>pyridine 
• 21924-90-3 11-phenyl-diindeno[1,2-b;2',1'-e]pyridine-10,12-dione 
• 129207-68-7 2-(α-phenylmercaptobenzyl)-1,3-indandione 
• 7443-10-9 2-(3-oxo-1,2,3-triphenyl-propyl)-indan-1,3-dione 
• 26576-80-7 3-Acetyl-2-methyl-4-phenyl-5-oxo-4,5-dihydro-1H-indeno<1,2-b>pyridine 
• 7421-80-9 2,2'-(phenylmethylene)bis(1H-indene-1,3(2H)-dione) 
• 172606-94-9 3-<α(1,3-dioxo-2-indanyl)benzyl>-2,4-pentanedione 
• 35929-88-5 3-benzoyl-2-methyl-4-phenyl-1,4-dihydro-indeno[1,2-b]pyridin-5-one 
• 68063-28-5 5-oxo-2,4-diphenyl-4,5-dihydro-1H-indeno[1,2-b]pyridine-3-carbonitrile 
• 1821-21-2 2-benzhydryl-1H-indene-1,3-(2H)-dione 
• 5014-04-0 2-benzhydryl-3-phenyl-inden-1-one 
• 7443-11-0 [(1,3-dioxo-indan-2-yl)-phenyl-methyl]-malonic acid diethyl ester 

Relevant articles and documents

Oxa-Michael–Michael Reaction of MBH Alcohol and 2-Arylidene-1,3-indanedione: Regioselective Formal [4+2] Cycloaddition towards Tetrahydrospiropyran Scaffolds

A regioselective formal [4+2] cycloaddition reaction of nitrostyrene derived MBH alcohol and 2-arylidene-1,3-indanedione resulted in functionalized tetrahydrospiropyran derivatives with excellent chemical yields (up to 93 %). The reaction tolerated variou

Synthesis of novel spiro-tetrahydroquinoline derivatives and evaluation of their pharmacological effects on wound healing

A highly diastereoselective method for the synthesis of novel spiro-tetrahydroquinoline derivatives is reported here, using a one-pot reaction method. All compounds were characterized by1 H-nuclear magnetic resonance (NMR) and mass spectroscopy

Phosphine-Catalyzed Cascade Michael Addition/[4+2] Cycloaddition Reaction of Allenoates and 2-Arylidene-1,3-indanediones

The phosphine-catalyzed cascade Michael addition/[4+2] cycloaddition reaction of tetrahydrobenzofuranone-derived allenoates and 2-arylidene-1,3-indanediones has been reported, affording spirocyclic 1,3-indanedione derivatives in moderate to high yields wi