113181-19-4Relevant academic research and scientific papers
[1,2,4]Triazolo[4,3-a]quinoxalin-4-amines: A new class of A1 receptor selective adenosine antagonists
Trivedi,Bruns
, p. 1011 - 1014 (1988)
Several [1,2,4]triazolo[4,3-a]quinoxalines that were reported as antidepressants in the patent literature were found to possess moderate affinity for the adenosine A1 and A2 receptors. On the basis of structural parallels with adenin
(1,2,4)triazolo(4,3-a)quinoxaline-4-amines
-
, (2008/06/13)
A unique series of [1,2,4]triazolo[4,3-a] quinoxaline-4-amine derivatives which show excellent binding affinity at both the A 1 and A 2 adenosine receptor sites. The compounds are useful in treating depression, fatigue, and heart failure. Also disclosed are methods for preparing the compounds, compositions containing the compounds and methods for using them.
