[1,2,4]Triazolo[4,3-a]quinoxalin-4-amines: A new class of A1 receptor selective adenosine antagonists

Article abstract of DOI:10.1021/jm00400a021

Several [1,2,4]triazolo[4,3-a]quinoxalines that were reported as antidepressants in the patent literature were found to possess moderate affinity for the adenosine A₁ and A₂ receptors. On the basis of structural parallels with adenin