1131985-40-4Relevant academic research and scientific papers
Hepatitis C virus NS3 protease inhibitors comprising a novel aromatic P1 moiety
Roenn, Robert,Lampa, Anna,Peterson, Shane D.,Gossas, Thomas,Akerblom, Eva,Danielson, U. Helena,Karlen, Anders,Sandstroem, Anja
, p. 2955 - 2967 (2008/09/20)
Inhibition of the hepatitis C virus (HCV) NS3 protease has emerged as an attractive approach to defeat the global hepatitis C epidemic. In this work, we present the synthesis and biochemical evaluation of HCV NS3 protease inhibitors comprising a non-natural aromatic P1 moiety. A series of inhibitors with aminobenzoyl sulfonamides displaying submicromolar potencies in the full-length NS3 protease assay was prepared through a microwave-irradiated, palladium-catalyzed, amidocarbonylation protocol.
