445306-08-1Relevant articles and documents
A systematic approach to the optimization of substrate-based inhibitors of the hepatitis C virus NS3 protease: Discovery of potent and specific tripeptide inhibitors
Llinàs-Brunet, Montse,Bailey, Murray D.,Ghiro, Elise,Gorys, Vida,Halmos, Ted,Poirier, Martin,Rancourt, Jean,Goudreau, Nathalie
, p. 6584 - 6594 (2007/10/03)
The inadequate efficacy and tolerability of current therapies for the infectious liver disease caused by the hepatitis C virus have warranted significant efforts in the development of new therapeutics. We have previously reported competitive peptide inhib
Substituted cycloalkyl P1' hepatitis C virus inhibitors
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Page/Page column 96; 97, (2010/02/06)
The present invention relates to tripeptide compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. In particular, the present invention provides novel tripeptide analogs, pharmaceutical compositions containing such analogs and methods for using these analogs in the treatment of HCV infection.