1132-42-9

Basic information

• Product Name: N-cyclohexylacetoacetamide
• Synonyms: N-cyclohexylacetoacetamide;N-Cyclohexyl-3-oxobutyramide
• CAS NO: 1132-42-9
• Molecular Formula: C₁₀H₁₇NO₂
• Molecular Weight: 183.24748
• EINECS: 214-475-9
• Mol File: 1132-42-9.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 361°Cat760mmHg
• Flash Point: 154.6°C
• Appearance: /
• Density: 1.03g/cm³
• Vapor Pressure: 2.13E-05mmHg at 25°C
• Refractive Index: 1.475
• CAS DataBase Reference: N-cyclohexylacetoacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-cyclohexylacetoacetamide(1132-42-9)
• EPA Substance Registry System: N-cyclohexylacetoacetamide(1132-42-9)

Safety Data

• Hazardous Substances Data: 1132-42-9(Hazardous Substances Data)

Usage

General Description

N-cyclohexylacetoacetamide is a chemical compound with the molecular formula C10H17NO2. It is a derivative of acetoacetic acid and is commonly used as an intermediate in the pharmaceutical and chemical industries for the synthesis of various pharmaceuticals and agrochemicals. N-cyclohexylacetoacetamide is also used as a reagent in organic synthesis and as a building block in the production of other complex molecules. It is a white to off-white crystalline solid with a melting point of around 53-56°C and is typically stored and handled under inert gas atmosphere to prevent decomposition. Additionally, it is known to exhibit low toxicity and is considered to be relatively safe for use in various industrial applications.

InChI:InChI=1/C10H17NO2/c1-8(12)7-10(13)11-9-5-3-2-4-6-9/h9H,2-7H2,1H3,(H,11,13)

Upstream product

• 5394-63-8 2,2,6-trimethyl-4H-1,3-dioxin-4-one 
• 108-91-8 cyclohexylamine 
• 1694-31-1 tert-butyl acetoacetate 
• 141-97-9 ethyl acetoacetate 
• 100877-69-8 3-tert-butylsulfanyl-crotonic acid cyclohexylamide 
• 674-82-8 4-methyleneoxetan-2-one 

Downstream Products

• 86072-19-7 methyl N-cyclohexyloxamate 
• 73964-79-1 N-cyclohexyl 4-oxo-pentanamide 
• 455927-10-3 N-cyclohexyl-6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide 
• 1351646-42-8 N-cyclohexyl-4-(2,4-dichlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide 
• 455927-56-7 N-cyclohexyl-4-(2,4-dichlorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide 
• 1398101-60-4 N-cyclohexyl-4,6-bis(4-methylphenyl)-2-methylnicotinamide 
• 536720-10-2 6-methyl-2-oxo-5-phenylcarbamoyl-1,2,3,4-tetrahydrospiro[pyridine-4,1'-cyclopentane]-3-carboxamide 
• 1314801-55-2 N-cyclohexyl-4-phenyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide 

Relevant articles and documents

CYCLIC DIARYLBORON DERIVATIVES AS NLRP3 INFLAMMASOME INHIBITORS

Inhibitor compounds are disclosed. The compounds are effective in the treatment of diseases or conditions in which interleukin 1 β activity is implicated. Methods of synthesis of the compounds, as well as pharmaceutical compositions comprising the compounds are also disclosed.

Fe(III) Complex Compounds For The Treatment And Prophylaxis Of Iron Deficiency Symptoms And Iron Deficiency Anemias

The invention relates to iron(III) complex compounds and pharmaceutical compositions comprising them for the use as medicaments, in particular for the treatment and/or prophylaxis of iron deficiency symptoms and iron deficiency anemias.

Mild and high-yielding synthesis of β-keto esters and β-ketoamides

In the presence of sodium acetate, the reaction between 2,2,6-trimethyl-4H-1,3-dioxin-4-one and secondary or tertiary alcohols (including chiral ones) or primary or secondary amines could be carried out in refluxing tetrahydrofuran, under much milder conditions than those described in the literature. In these new conditions, side products normally observed using the traditional protocol were avoided, and-keto esters and-ketoamides were normally obtained in quantitative yields.