113231-57-5

Upstream product

• 113231-76-8 7-Diethylamino-3-(1-hydroxy-2-phenyl-ethyl)-chromen-2-one 
• 17754-90-4 4-(Diethylamino)salicylaldehyde 
• 113231-63-3 3-[1-(4-Diethylamino-2-hydroxy-phenyl)-meth-(Z)-ylidene]-5-phenyl-3H-furan-2-one 
• 113231-69-9 7-Diethylamino-3-phenylacetyl-chromen-2-one 
• 2051-95-8 succinylbenzene 
• 100-42-5 styrene 
• 133590-13-3 3-bromo-7-(diethylamino)-2H-chromen-2-one 

Relevant academic research and scientific papers

A novel coumarin derivative as a sensitive probe for tracing intracellular pH changes

A new pH sensitive probe, 7-diethylamino-3-[2-(4-piperidin-1-yl-phenyl)-vinyl]-chromen-2-one (CS-P), was designed and synthesized. This probe was constructed by introduction of piperidine to the coumarin stem. It exhibited high pH sensitivity ranging from pH 5.9 to pH 3.0 (pKa = 4.55), and in vitro cell imaging showed that its fluorescence intensity was distinctly related to the cellular pH changes induced by chloroquine or dexamethasone. Demonstrated as having good cell membrane permeability and high pH sensitivity, this probe is suitable for tracing the intracellular pH changes from neutral to acidic conditions. This journal is

Snythesis of 3-Styrylcoumarins from Coumarin-3-acetic Acids and 3-Phenacylcoumarins

The hitherto unknown 3-styrylcoumarin system has been synthesised by two routes.In the first approach, coumarin-3-acetic acids are reacted with aromatic aldehydes to yield directly the 3-styrylcoumarins.The synthesis is limited by the difficulty in obtaining coumarin-3-acetic acids in good yields.The second approach utilises 3-phenacylcoumarins which are reduced to the carbinols and subsequently dehydrated to the corresponding 3-styrylcoumarins.The fluorescence of these compounds and their application to polyester fibre have been studied.