113248-64-9

Usage

Uses

Used in Pharmaceutical Research and Development:
(4-FLUORO-BENZYL)-PYRIDIN-3-YLMETHYL-AMINE is used as a chemical intermediate for the synthesis of potential drug candidates. Its unique structure and functional groups make it a valuable component in the development of new medications with specific therapeutic targets.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (4-FLUORO-BENZYL)-PYRIDIN-3-YLMETHYL-AMINE is employed as a key building block in the design and synthesis of novel compounds with potential therapeutic applications. Its presence in a molecule can influence the pharmacological properties, such as binding affinity, selectivity, and bioavailability, of the resulting drug candidates.
Used in Drug Discovery:
(4-FLUORO-BENZYL)-PYRIDIN-3-YLMETHYL-AMINE plays a crucial role in drug discovery, where it is used to explore the structure-activity relationships of various biologically active compounds. By incorporating (4-FLUORO-BENZYL)-PYRIDIN-3-YLMETHYL-AMINE into different molecular frameworks, researchers can gain insights into the molecular interactions and mechanisms of action, ultimately leading to the identification of promising drug candidates.

InChI:InChI=1/C13H13FN2/c14-13-5-3-11(4-6-13)8-16-10-12-2-1-7-15-9-12/h1-7,9,16H,8,10H2/p+1

Upstream product

• 500-22-1 3-pyridinecarboxaldehyde 
• 745814-24-8 C₁₃H₁₁FN₂ 
• 3731-52-0 3-Aminomethylpyridine 
• 459-57-4 4-fluorobenzaldehyde 
• 140-75-0 para-fluorobenzylamine 

Relevant academic research and scientific papers

4-(N,N-diarylmethylamine)furan-2(5H)-one derivatives, and preparation method and application thereof

The invention discloses 4-(N,N-diarylmethylamine)furan-2(5H)-one derivatives, and a preparation method and application thereof. The derivatives are as shown in a general formula (I) which is describedin the specification. In the formula (I), R1 is 6-chloropyridin-3-yl, pyridin-3-yl, 6-fluoropyridin-3-yl, 6-bromopyridin-3-yl or 6-trifluoromethylpyridin-3-yl; R2 is 4-chloro-3-fluorobenzyl, thienyl,2,4,5-trifluorobenzyl, 4-trifluoromethylbenzyl, 2,6-difluorobenzyl, 4-bromobenzyl, 2-chloro-6-fluorobenzyl, 2-fluorobenzyl, 3,4-difluorobenzyl, 3-chloro-4-fluorobenzyl, 3,4,5-trifluorobenzyl, 2,4,6-trifluoro Benzyl, 4-fluoro-2-methylbenzyl, 3-bromo-4-fluorobenzyl, 2-fluorobenzonitrile, 4-fluoro-3-methylbenzyl, 3,4-dichlorobenzyl, 2-chlorobenzyl, 2,4,5-trifluorobenzyl, 4-fluorobenzyl, 3-bromobenzyl, 3-chlorobenzyl, 2,3,4,5,6-pentafluorobenzyl, 4-fluoro-3-nitrobenzyl, 5-chloro-2-fluorobenzyl, cyanobenzyl, 3-nitrobenzyl or 4-((3,3-dichloroallyl)oxy)benzyl. The derivatives provided by the invention have good activity on aphids attacking broad beans; preparation process is simple; and production cost is low.

Optimized chemical probes for REV-ERBα

REV-ERBα has emerged as an important target for regulation of circadian rhythm and its associated physiology. Herein, we report on the optimization of a series of REV-ERBα agonists based on GSK4112 (1) for potency, selectivity, and bioavailability.(1) Potent REV-ERBα agonists 4, 10, 16, and 23 are detailed for their ability to suppress BMAL and IL-6 expression from human cells while also demonstrating excellent selectivity over LXRα. Amine 4 demonstrated in vivo bioavailability after either iv or oral dosing.

Flow synthesis of organic azides and the multistep synthesis of imines and amines using a new monolithic triphenylphosphine reagent

Here we describe general flow processes for the synthesis of alkyl and aryl azides, and the development of a new monolithic triphenylphosphine reagent, which provides a convenient format for the use of this versatile reagent in flow. The utility of these new tools was demonstrated by their application to a flow Staudinger aza-Wittig reaction sequence. Finally, a multistep aza-Wittig, reduction and purification flow process was designed, allowing access to amine products in an automated fashion.