113251-41-5

Upstream product

• 113251-32-4 trans-8-thiabicyclo<4.3.0>nonan-3β-ol 
• 65-85-0 benzoic acid 
• 113251-38-0 diethyl trans-4-oxocyclohexane-1,2-dicarboxylate 
• 113251-39-1 trans-4,4-diethoxy-1,2-bis(hydroxymethyl)cyclohexane 
• 113251-40-4 trans-4,4-diethoxy-1,2-bis(hydroxymethyl)cyclohexane bis(toluenesulfonate) 
• 113251-27-7 trans-8-thiabicyclo<4.3.0>nonan-3-one 

Relevant academic research and scientific papers

Enzymes in Organic Synthesis. 41. Stereoselective Horse Liver Alcohol Dehydrogenase Catalyzed Reductions of Heterocyclic Bicyclic Ketones

Preparative-scale horse liver alcohol dehydrogenase catalyzed reductions of racemic cis and trans bicyclic O- and S-heterocyclic ketones proceed with high enantiomeric selectivity.The diastereotopic selectivity for the pro-R faces of the carbonyl groups is also very high.The ee's of all but one of the product alcohols are >97percent.The ee's of the recovered ketones are in the 52-60percent range.The results confirm that an ether-oxygen or -sulfur substituent does not alter the enzyme's overall structural specificity or stereospecificity toward its ketone substrates.